1,1,1-三(羟甲基)乙烷合成路线 （共 76 条）
反应条件
in N,N-dimethyl-formamide
T=20°C; 2 h; Molecular sieve;
参考文献
Tange, Seiko; Fukuhara, Tsuyoshi; Hara, Shoji
Synthesis, 2008 , # 20 p. 3219 - 3222
反应条件
toluene-4-sulfonic acid
T=100°C; P=0.1 Torr;
参考文献
McClelland, Robert A.; Gedge, Sherrin; Bohonek, Jon
Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 886 - 891
反应条件
1: 64 percent / ethyl carbonate, KOH / ethanol / 0.25 h / Heating
2: 70 percent / pyridine / CH2Cl2
3: 41 percent / BF3*Et2O / CH2Cl2 / 24 h / Ambient temperature
View Scheme
参考文献
Rakus, Klaus; Verevkin, Sergey P.; Peng, Wei-Hong; Beckhaus, Hans-Dieter; Ruechardt, Christoph
Liebigs Annalen, 1995 , # 12 p. 2059 - 2068
参考文献
Atkins, Martin P.; Golding, Bernard T.; Howes, David A.; Sellars, Philip J.
Journal of the Chemical Society, Chemical Communications, 1980 , # 5 p. 207 - 208
反应条件
1: 66 percent / benzene / Heating
2: 65 percent / NaI, NaHCO3 / acetone
View Scheme
参考文献
Atkins, Martin P.; Golding, Bernard T.; Howes, David A.; Sellars, Philip J.
Journal of the Chemical Society, Chemical Communications, 1980 , # 5 p. 207 - 208
反应条件
sodium hydroxide in dichloromethane; water
T=10 - 20°C;
参考文献
Dupuy; Viguier; Dupraz
Synthetic Communications, 2001 , vol. 31, # 9 p. 1307 - 1313
参考文献
Doering; Levy
Journal of the American Chemical Society, 1955 , vol. 77, p. 509,512
反应条件
toluene; benzenesulfonic Acid
参考文献
Barnes; Fainman
Lubrication Eng., 1957 , vol. 13, p. 454,455
反应条件
1: 81 percent / p-toluenesulfonic acid / benzene / 5 h
2: 1) NaH (80percent in paraffine oil) / 1) anh. THF, 30 min, r. t., 2) THF, 6 h, reflux
3: 88 percent / 0.2N H2SO4 / 16 h / Heating
4: 48 percent / NaH (80percent in paraffine oil) / tetrahydrofuran / 12 h / Heating
5: 97 percent / H2, Pd/C (10percent) / ethanol / 4 h / Ambient temperature
View Scheme
参考文献
Weber, Edwin
Liebigs Annalen der Chemie, 1983 , # 5 p. 770 - 801
反应条件
in tetrahydrofuran
T=40°C; 3 h;
参考文献
Corey, E. J.; Shimoji, Katsuichi
Journal of the American Chemical Society, 1983 , vol. 105, # 6 p. 1662 - 1664
