4-氨基-2-甲巯基嘧啶-5-甲醛合成路线 （共 13 条）
反应条件
1: 88 percent / tetrahydrofuran; diethyl ether 2: 42 percent / 4A molecular sieves; N-methyl morpholine oxide; tetrapropylammonium perruthenate / CH2Cl2 / 20 °C View Scheme
参考文献
VanderWel, Scott N.; Harvey, Patricia J.; McNamara, Dennis J.; Repine, Joseph T.; Keller, Paul R.; Quin III, John; Booth, R. John; Elliott, William L.; Dobrusin, Ellen M.; Fry, David W.; Toogood, Peter L.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2371 - 2387
反应条件
1: 75 percent / tetrahydrofuran / 3 h / Heating 2: 45 percent / N,N-diisopropylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / Heating View Scheme
参考文献
Barvian; Boschelli; Cossrow; Dobrusin; Fattaey; Fritsch; Fry; Harvey; Keller; Garrett; La; Leopold; McNamara; Quin; Trumpp-Kallmeyer; Toogood; Wu; Zhang
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4606 - 4616
反应条件
1.1: NaH / tetrahydrofuran / 1.5 h / 20 °C
1.2: tetrahydrofuran / 20 °C
2.1: 18.30 g / 2-(phenylsulfonyl)-3-phenyloxaziridine / CHCl3 / 24 h / 20 °C
3.1: 72 percent / dioxane / 50 °C
View Scheme
参考文献
Thompson, Andrew M.; Delaney, Amy M.; Hamby, James M.; Schroeder, Mel C.; Spoon, Teresa A.; Crean, Sheila M.; Showalter, H. D. Hollis; Denny, William A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4628 - 4653
