4-[[(6S,8S,9S,10R,11S,13S,14S,17R)-11-羟基-17-(2-羟基乙酰基)-6,10,13-三甲基-3-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊并[a]菲-17-基]氧基]-4-氧代丁酸合成路线 （共 5 条）
77074-42-14-[[(6S,8S,9S,10R,11S,13S,14S,17R)-11-羟基-17-(2-羟基乙酰基)-6,10,13-三甲基-3-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊并[a]菲-17-基]氧基]-4-氧代丁酸
→
反应条件
aq. buffer in N,N-dimethyl-formamide T=25°C; pH dependence; Rate constantMechanism;
参考文献
Anderson; Conradi; Lambert
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 5 p. 604 - 610
77074-42-14-[[(6S,8S,9S,10R,11S,13S,14S,17R)-11-羟基-17-(2-羟基乙酰基)-6,10,13-三甲基-3-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊并[a]菲-17-基]氧基]-4-氧代丁酸
→
反应条件
aq. buffer in N,N-dimethyl-formamide T=25°C; pH dependence; Rate constantMechanism;
参考文献
Anderson; Conradi; Lambert
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 5 p. 604 - 610
77074-42-14-[[(6S,8S,9S,10R,11S,13S,14S,17R)-11-羟基-17-(2-羟基乙酰基)-6,10,13-三甲基-3-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊并[a]菲-17-基]氧基]-4-氧代丁酸
→
反应条件
in water T=25°C; Rate constant;
参考文献
Anderson; Taphouse
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 2 p. 181 - 186
→
77074-42-14-[[(6S,8S,9S,10R,11S,13S,14S,17R)-11-羟基-17-(2-羟基乙酰基)-6,10,13-三甲基-3-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊并[a]菲-17-基]氧基]-4-氧代丁酸
反应条件
water in acetonitrile
T=25°C; Rate constant;
参考文献
Anderson; Conradi; Johnson
Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 4 p. 448 - 454
→
77074-42-14-[[(6S,8S,9S,10R,11S,13S,14S,17R)-11-羟基-17-(2-羟基乙酰基)-6,10,13-三甲基-3-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊并[a]菲-17-基]氧基]-4-氧代丁酸
反应条件
aq. buffer in N,N-dimethyl-formamide
T=25°C; pH dependence; Rate constantMechanism;
参考文献
Anderson; Conradi; Lambert
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 5 p. 604 - 610
