2,3,4,5,6-五氟苯胺合成路线 （共 126 条）
反应条件
dihydrogen peroxide in dichloromethane reflux in boiling solvent and heating with stirring 1-2.5 h; destillation;
参考文献
Journal of the Chemical Society, , p. 802 - 807
反应条件
sulfuric acid; water; sodium nitrite in sulfuric acid Diazotation for 2 h at 0°C then treated in water at 90-95°C for 0.5 h.; extracted with ether;
参考文献
Journal of the Chemical Society, , p. 2088 - 2094
参考文献
Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q.
Patent: US2004/29887 A1, 2004 ;
反应条件
H2SO4, NaNO2, Na2CO3 in sulfuric acid 2 h with NaNO2, added Na2CO3, stirred at 0°C for 2 h, added 70percent H2SO4 and H3PO2, warmed on waterbath for 0.75 h.;
参考文献
Gmelin Handbook: F: PerFHalOrg.7, 1, page 1 - 84
反应条件
hydrogen iodide; potassium iodide 12 h; Heating;
参考文献
Kobayashi,H.; Sonoda,T.
Journal of Fluorine Chemistry, 1985 , vol. 27, p. 1
反应条件
1: benzenesulfonyl chloride With pyridine; 4-(N,N-dimethlyamino)pyridine T=20°C; 0.25 h; 2: 2,3,4,5,6-pentafluoroaniline Heating;
参考文献
Dai, Hui-Xiong; Stepan, Antonia F.; Plummer, Mark S.; Zhang, Yang-Hui; Yu, Jin-Quan
Journal of the American Chemical Society, 2011 , vol. 133, # 18 p. 7222 - 7228
反应条件
triethylamine in dichloromethane T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Matsumoto, Yotaro; Noguchi-Yachide, Tomomi; Nakamura, Masaharu; Mita, Yusuke; Numadate, Akiyoshi; Hashimoto, Yuichi
Heterocycles, 2012 , vol. 86, # 2 p. 1449 - 1463
反应条件
in 1,2-dichloro-benzene at 120-130°C (1.5 h) stirring) then heating to 180°C with introduction of COCl2 (6 h);
参考文献
Malichenko, B. F.; Penchuk, V. V.
Zhurnal Obshchei Khimii, 1968 , vol. 38, p. 2413 - 2414
Zhurnal Obshchei Khimii, 1968 , vol. 38, p. 2497 - 2499
C.A., 1969 , vol. 70, p. 46986
Full Text Show Details
Malichenko, B. F.
Patent: SU241427 , 1969 ;
C.A., 1969 , vol. 71, p. 80912
反应条件
T=100°C; 8 h; Inert atmosphere;
参考文献
Song, Liping; Song, Shaodi; Huang, Jiling
Chinese Journal of Chemistry, 2012 , vol. 30, # 5 p. 1119 - 1126
反应条件
1: molecular sieves / toluene / 48 h / Heating 2: NaBH4 / methanol / 4 h / 20 °C View Scheme
参考文献
Casey, Charles P.; Johnson, Jeffrey B.
Journal of the American Chemical Society, 2005 , vol. 127, # 6 p. 1883 - 1894
