4,7-二甲氧基-(9ci)-1H-苯并咪唑合成路线 （共 11 条）
反应条件
sodium hydride in N,N-dimethyl-formamide 12 h;
参考文献
Alvarez, Frederic; Taleb, Abbas; Gentili, Jacques; Nebois, Pascal; Terreux, Raphael; Domard, Monique; Thozet, Alain; Merle, Daphne; Fillion, Houda; Walchshofer, Nadia
European Journal of Organic Chemistry, 2005 , # 9 p. 1903 - 1908
反应条件
1: 4,7-dimethoxy-1H-benzimidazole With sodium hydride in N,N-dimethyl-formamide T=20°C; 2: benzyl halide in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
Alvarez, Frederic; Gherardi, Arnaud; Nebois, Pascal; Sarciron, Marie-Elizabeth; Petavy, Anne-Francoise; Walchshofer, Nadia
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 6 p. 977 - 979
反应条件
hydrogenchloride; nitric acid T=20°C; 2 h;
参考文献
Chung, Kwang-Hoe; Hong, Sung-Yu; You, Hea-Jung; Park, Rae-Eun; Ryu, Chung-Kyu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 17 p. 5795 - 5801
反应条件
1: 1,4-dimethoxy benzene With nitric acid; acetic anhydride
T=0°C; 3 h;
2: With hydrogenchloride; tin
2 h; Heating;
3: formic acid 5 h; Heating;
参考文献
Alvarez, Frederic; Gherardi, Arnaud; Nebois, Pascal; Sarciron, Marie-Elizabeth; Petavy, Anne-Francoise; Walchshofer, Nadia
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 6 p. 977 - 979
反应条件
1.1: conc. HNO3 / acetic anhydride / 0 °C
1.2: Sn; conc. HCl / 100 °C
2.1: 4.75 g / 5.5 h / Heating
View Scheme
参考文献
Taleb, Abbass; Alvarez, Frederic; Nebois, Pascal; Walchshofer, Nadia
Heterocyclic Communications, 2006 , vol. 12, # 2 p. 111 - 114
反应条件
1: conc. HCl; tin / 3 h / 100 °C
2: 4.75 g / 5.5 h / Heating
View Scheme
参考文献
Taleb, Abbass; Alvarez, Frederic; Nebois, Pascal; Walchshofer, Nadia
Heterocyclic Communications, 2006 , vol. 12, # 2 p. 111 - 114
参考文献
Weinberger; Day
Journal of Organic Chemistry, 1959 , vol. 24, p. 1451,1452, 1453
反应条件
Phillips cyclization; 5.5 h; Heating;
参考文献
Taleb, Abbass; Alvarez, Frederic; Nebois, Pascal; Walchshofer, Nadia
Heterocyclic Communications, 2006 , vol. 12, # 2 p. 111 - 114
反应条件
1: 48 percent aq. HBr / 5 h / 125 °C
2: 0.7 M aq. FeCl3 / 0.5 h / 20 °C
View Scheme
参考文献
Weinberger; Day
Journal of Organic Chemistry, 1959 , vol. 24, p. 1451,1452, 1453
反应条件
1: 4,7-dimethoxy-1H-benzimidazole With potassium hydroxide in acetone
T=20°C;
2: methyl iodide in acetone
T=20°C; 12 h;
参考文献
Alvarez, Frederic; Gherardi, Arnaud; Nebois, Pascal; Sarciron, Marie-Elizabeth; Petavy, Anne-Francoise; Walchshofer, Nadia
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 6 p. 977 - 979
