(9ci)-4,7-二甲氧基-1-甲基-1H-苯并咪唑合成路线 （共 3 条）
反应条件
1: 4,7-dimethoxy-1H-benzimidazole With potassium hydroxide in acetone
T=20°C;
2: methyl iodide in acetone
T=20°C; 12 h;
参考文献
Alvarez, Frederic; Gherardi, Arnaud; Nebois, Pascal; Sarciron, Marie-Elizabeth; Petavy, Anne-Francoise; Walchshofer, Nadia
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 6 p. 977 - 979
反应条件
in toluene
12 h; Heating;
参考文献
Middleton; Monney; Parrick
Synthesis, 1984 , vol. NO. 9, p. 740 - 743
反应条件
1.1: 70 percent aq. HNO3; Ac2O / 3 h / 0 °C
1.2: Sn; 12 N aq. HCl / 2 h / Heating
1.3: 5 h / Heating
2.1: KOH / acetone / 20 °C
2.2: acetone / 12 h / 20 °C
View Scheme
参考文献
Alvarez, Frederic; Gherardi, Arnaud; Nebois, Pascal; Sarciron, Marie-Elizabeth; Petavy, Anne-Francoise; Walchshofer, Nadia
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 6 p. 977 - 979
