(S)-1-苯基-3-丁烯-1-醇合成路线 （共 84 条）
反应条件
Yield given. Multistep reaction;
参考文献
Jadhav, Prabhakar K.; Bhat, Krishna S.; Perumal, P. Thirumalai; Brown, Herbert C.
Journal of Organic Chemistry, 1986 , vol. 51, # 4 p. 432 - 439
反应条件
chiral 2,2'-bipyridine N,N'-dioxide based compound; N-ethyl-N,N-diisopropylamine in acetonitrile
T=-45°C; 2.5 h; Title compound not separated from byproducts;
参考文献
Shimada, Toyoshi; Kina, Asato; Hayashi, Tamio
Journal of Organic Chemistry, 2003 , vol. 68, # 16 p. 6329 - 6337
反应条件
1: in diethyl ether; dichloromethane
T=-100°C;
2: With sodium hydroxide; dihydrogen peroxide in diethyl ether; dichloromethane; water
Heating; Further stages. Title compound not separated from byproducts.;
参考文献
Melancon, Bruce J.; Perl, Nicholas R.; Taylor, Richard E.
Organic Letters, 2007 , vol. 9, # 8 p. 1425 - 1428
反应条件
in diethyl ether
-78°C, 3 h; NMR;
参考文献
Burgos, Carlos H.; Canales, Eda; Matos, Karl; Soderquist, John A.
Journal of the American Chemical Society, 2005 , vol. 127, # 22 p. 8044 - 8049
反应条件
(S)-1-n-butyl-2-lt;(piperidin-1-yl)methylgt;pyrrolidine in dichloromethane
T=-78°C;
参考文献
Kobayashi, Shu
Tetrahedron Letters, 1995 , vol. 36, # 37 p. 6729 - 6732
反应条件
(1r,2r)-(-)-pseudoephedrine in acetonitrile
2 h; Heating;
参考文献
Burgos, Carlos H.; Canales, Eda; Matos, Karl; Soderquist, John A.
Journal of the American Chemical Society, 2005 , vol. 127, # 22 p. 8044 - 8049
反应条件
1: SnCl4 / acetonitrile / -15 °C
2: PCC
3: 1.) MCPBA, 2.) p-TSA*pyridine / 1.) CH2Cl2, room temperature, 2.) MeOH, 60 deg
View Scheme
参考文献
McNamara, J. M.; Kishi, Y.
Journal of the American Chemical Society, 1982 , vol. 104, # 25 p. 7371 - 7372
反应条件
1: 3-chloroprop-1-ene With manganese; triethylamine; Cr(II)(salen) in acetonitrile
T=20°C; 1 h;
2: chloro-trimethyl-silane; benzaldehyde in acetonitrile
Nozaki-Hiyama reaction;
3: With hydrogenchloride in tetrahydrofuran
Title compound not separated from byproducts;
参考文献
Bandini, Marco; Cozzi, Pier Giorgio; Umani-Ronchi, Achille
Tetrahedron, 2001 , vol. 57, # 5 p. 835 - 843
反应条件
Pseudomonas cepacia Amano PS lipase in 2,2,4-trimethylpentane
T=30°C; 48 h; Title compound not separated from byproducts;
参考文献
Kawasaki, Masashi; Kakuda, Hiroko; Goto, Michimasa; Kawabata, Shigeki; Kometani, Tadashi
Tetrahedron Asymmetry, 2003 , vol. 14, # 11 p. 1529 - 1534
反应条件
1: BAll3 With (R)-3,3'-diphenylBINOL in tetrahydrofuran
1 h; Heating;
2: benzaldehyde in tetrahydrofuran
T=-78°C; 1 h; Title compound not separated from byproducts;
参考文献
Wu, T. Robert; Shen, Lixin; Chong, J. Michael
Organic Letters, 2004 , vol. 6, # 16 p. 2701 - 2704
