N-Boc-D-苯丙氨醛合成路线 （共 14 条）
反应条件
1: With diisobutylaluminium hydride in dichloromethane; toluene T=-78°C; 1 h; Inert atmosphere; 2: With methanol; Potassium sodium tartrate in dichloromethane; toluene T=20°C;
参考文献
PHENEX PHARMACEUTICALS AG; KINZEL, Olaf; STEENECK, Christoph; KLEYMANN, Gerald; ALBERS, Michael; HOFFMANN, Thomas; KREMOSER, Claus; PEROVIC-OTTSTADT, Sanja; SCHLUeTER, Thomas
Patent: WO2011/107248 A1, 2011 ;
Location in patent: Page/Page column 68; 69 ;
WO 2011/107248 A1
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-60°C; Swern Oxidation; 0.166667 h; Cooling with acetone-dry ice; 2: t-butyl (1R)-1-benzyl-2-hydroxyethylcarbamate in dichloromethane T=-60°C; 0.25 h; 3: With N-ethyl-N,N-diisopropylamine in dichloromethane T=-60°C; 0.0833333 h;
参考文献
MENARINI RICERCHE S.P.A.
Patent: WO2004/94412 A1, 2004 ;
Location in patent: Page 10 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; Reduction; 1 h;
参考文献
Fukumizu, Atsuko; Tsuda, Yuko
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 8 p. 1141 - 1144
反应条件
1: CDI, DIEA / tetrahydrofuran; dimethylformamide / Ambient temperature 2: LiAlH4 / diethyl ether / 0.5 h / 0 - 5 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 18 p. 2918 - 2929
反应条件
lithium aluminium tetrahydride in diethyl ether T=-50°C; 0.333333 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 56, # 13 p. 4161 - 4167
反应条件
1: dioxane / Ambient temperature 2: 1.) 4A molecular sieves, MeOTf, 2.) NaBH4, 3.) CuO, CuCl2 View Scheme
参考文献
Synthesis, , # 5 p. 641 - 646
反应条件
1: NaHCO3 / H2O; tetrahydrofuran / Ambient temperature 2: diisobutylaluminium hydride / toluene; hexane / -77 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 2 p. 211 - 220
反应条件
1: dioxane / Ambient temperature 2: 1.) 4A molecular sieves, MeOTf, 2.) NaBH4, 3.) CuO, CuCl2 View Scheme
参考文献
Synthesis, , # 5 p. 641 - 646
反应条件
1: NaOH, hydroxylamine hydrochloride, HOAc / methanol / 5 h / 0 °C 2: dioxane / Ambient temperature 3: 1.) 4A molecular sieves, MeOTf, 2.) NaBH4, 3.) CuO, CuCl2 View Scheme
参考文献
Synthesis, , # 5 p. 641 - 646
反应条件
1: NaOH, hydroxylamine hydrochloride, HOAc / methanol / 5 h / 0 °C 2: dioxane / Ambient temperature 3: 1.) 4A molecular sieves, MeOTf, 2.) NaBH4, 3.) CuO, CuCl2 View Scheme
参考文献
Synthesis, , # 5 p. 641 - 646
