2-(4-溴苯基)-N-甲基乙酰胺合成路线 （共 6 条）
反应条件
1: 2-(4-bromophenyl)acetic acid With thionyl chloride; N,N-dimethyl-formamide in toluene T=35 - 40°C; 2 h; Large scale reaction; 2: methylamine in water; toluene T=0 - 25°C; 19 h; Large scale reaction;
参考文献
Ulysse, Luckner G.; Yang, Qiang; McLaws, Mark D.; Keefe, Daniel K.; Guzzo, Peter R.; Haney, Brian P.
Organic Process Research and Development, 2010 , vol. 14, # 1 p. 225 - 228
反应条件
in water; toluene T=0 - 20°C; 1 h;
参考文献
Organic Process Research and Development, , vol. 14, # 1 p. 225 - 228
参考文献
Tetrahedron, , vol. 22, p. 2995 - 2999
反应条件
1: aq. NaOH / Heating 2: 135 °C View Scheme
参考文献
Tetrahedron, , vol. 22, p. 2995 - 2999
反应条件
phosphorous pentoxide in methanesulfonic acid
T=19 - 80°C; Large scale reaction;
参考文献
Ulysse, Luckner G.; Yang, Qiang; McLaws, Mark D.; Keefe, Daniel K.; Guzzo, Peter R.; Haney, Brian P.
Organic Process Research and Development, 2010 , vol. 14, # 1 p. 225 - 228
反应条件
1: phosphoric acid / 160 °C
2: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 30 h / 85 °C / Large scale reaction
View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
