5,7-二氯-3-异丙基吡唑并[1,5-a]嘧啶合成路线 （共 5 条）
反应条件
N,N-dimethyl-aniline; trichlorophosphate
16 h; Heating / reflux;
参考文献
VERNALIS (CAMBRIDGE) LIMITED
Patent: WO2004/87707 A1, 2004 ;
Location in patent: Page 27; 29 ;
WO 2004/087707 A1
反应条件
trichlorophosphate
16 h; Heating / reflux;
参考文献
EMORY UNIVERSITY; IMPERIAL COLLEGE OF SCIENCE AND TECHNOLOGY; JOGALEKAR, Ashutosh, S.
Patent: WO2008/151304 A1, 2008 ;
Location in patent: Page/Page column 113-115 ;
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C
1.2: 16.5 h / -78 - 20 °C
2.1: hydrazine hydrate; acetic acid / ethanol / 16 h / Reflux
3.1: ethanol; sodium / 16 h / Reflux
3.2: pH 3
4.1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / Reflux
View Scheme
参考文献
Liotta, Dennis C.; Snyder, James P.; Jogalekar, Ashutosh S.; Barrett, Anthony G.M.; Fuchter, Matthew John; Cook, Matthew J.; Kroll, Sebastian H.B.
Patent: US2012/41198 A1, 2012 ;
US 20120041198 A1
反应条件
1.1: hydrazine hydrate; acetic acid / ethanol / 16 h / Reflux
2.1: ethanol; sodium / 16 h / Reflux
2.2: pH 3
3.1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / Reflux
View Scheme
参考文献
Liotta, Dennis C.; Snyder, James P.; Jogalekar, Ashutosh S.; Barrett, Anthony G.M.; Fuchter, Matthew John; Cook, Matthew J.; Kroll, Sebastian H.B.
Patent: US2012/41198 A1, 2012 ;
US 20120041198 A1
反应条件
1.1: ethanol; sodium / 16 h / Reflux
1.2: pH 3
2.1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / Reflux
View Scheme
参考文献
Liotta, Dennis C.; Snyder, James P.; Jogalekar, Ashutosh S.; Barrett, Anthony G.M.; Fuchter, Matthew John; Cook, Matthew J.; Kroll, Sebastian H.B.
Patent: US2012/41198 A1, 2012 ;
US 20120041198 A1
