2-溴-6-(2,5-二甲基-1H-吡咯-1-基)-4-甲基-吡啶合成路线 （共 2 条）
反应条件
toluene-4-sulfonic acid in toluene
T=150°C; 1 h; Microwave irradiation;
参考文献
Kang, Soosung; Tang, Wei; Li, Huiying; Chreifi, Georges; Martasek, Pavel; Roman, Linda J.; Poulos, Thomas L.; Silverman, Richard B.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 10 p. 4382 - 4396
反应条件
1: HBr; AcOH / 2 h / 20 °C
2: p-TsOH*H2O / toluene / 1.5 h / Heating
View Scheme
参考文献
Buettelmann, Bernd; Peters, Jens-Uwe; Ceccarelli, Simona; Kolczewski, Sabine; Vieira, Eric; Prinssen, Eric P.; Spooren, Will; Schuler, Franz; Huwyler, Joerg; Porter, Richard H. P.; Jaeschke, Georg
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1892 - 1897
