4-羟基-6-甲氧基喹啉-3-羧酸乙酯合成路线 （共 16 条）
反应条件
in dowtherm A T=250°C; 1.5 h; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/2047 A2, 2006 ;
Location in patent: Page/Page column 60 ;
反应条件
dowtherm A in ethanol 0.5 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/14580 A1, 2006 ;
Location in patent: Page/Page column 38 ;
反应条件
in diphenylether; ethyl acetate
参考文献
Tsunoda, Hidetoshi; Fukazawa, Nobuyuki; Nagase, Hiroshi; Chiba, Kyoko; Nakao, Toshifumi; Asada, Noriaki; Yamaki, Toshifumi; Kibayashi, Kenji; Migita, Hideyuki; Morikawa, Maki
Patent: US2003/212100 A1, 2003 ;
参考文献
SENOMYS, INC.
Patent: US2011/245353 A1, 2011 ;
Title/Abstract Full Text Show Details
SENOMYX, INC.
Patent: US2012/41078 A1, 2012 ;
反应条件
1: 2 h / 110 - 115 °C 2: various solvent(s) / 0.5 h / 250 °C View Scheme
参考文献
Farmaco, , vol. 53, # 8-9 p. 579 - 585
反应条件
1: ethanol / 4 h / 85 °C 2: Dowtherm™ A / 3 h / 250 °C View Scheme
反应条件
1: aq. sodium hydroxide / 1 h / Heating 2: diphenyl ether / 1 h / Heating View Scheme
参考文献
Ramsey; Cretcher
Journal of the American Chemical Society, 1947 , vol. 69, p. 1659,1660
参考文献
Suzuki, Hiroshi; Aly, Nagwa S. M.; Wataya, Yusuke; Kim, Hye-Sook; Tamai, Ikumi; Kita, Masaki; Uemura, Daisuke
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 5 p. 821 - 824
反应条件
1.1: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C 2.1: sodium hydroxide / tetrahydrofuran / 0 - 20 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C 3.2: 2 h / 0 °C 4.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
1: aqueous NaOH 2: diphenyl ether / 245 °C 3: phosphoryl chloride; phosphorus (V)-chloride / 115 °C View Scheme
参考文献
Ramsey; Cretcher
Journal of the American Chemical Society, 1947 , vol. 69, p. 1659,1660
