4-羟基-6-甲氧基喹啉-3-羧酸乙酯合成路线 （共 16 条）
反应条件
in trichlorophosphate
参考文献
SENOMYX, INC.; TACHDJIAN, Catherine; TANG, Xiao Qing; KARANEWSKY, Donald S.; SERVANT, Guy; LI, Xiaodong; ZHANG, Feng; CHEN, Qing; ZHANG, Hong; DAVIS, Timothy; DARMOHUSODO, Vincent; WONG, Melissa; SELCHAU, Victor
Patent: WO2013/25560 A1, 2013 ;
Location in patent: Page/Page column 52; 53 ;
反应条件
1: aqueous NaOH 2: diphenyl ether / 245 °C 3: phosphoryl chloride; phosphorus (V)-chloride / 115 °C 4: water; sulfuric acid View Scheme
参考文献
Ramsey; Cretcher
Journal of the American Chemical Society, 1947 , vol. 69, p. 1659,1660
反应条件
1: With phosphorus tribromide in N,N-dimethyl-formamide
T=20°C; 1 h;
2: With sodium hydrogencarbonate in water; N,N-dimethyl-formamide
Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/2047 A2, 2006 ;
Location in patent: Page/Page column 61 ;
反应条件
1: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C
2: sodium hydroxide / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
1: trichlorophosphate
2: ammonia / isopropyl alcohol
View Scheme
参考文献
SENOMYX, INC.; TACHDJIAN, Catherine; TANG, Xiao Qing; KARANEWSKY, Donald S.; SERVANT, Guy; LI, Xiaodong; ZHANG, Feng; CHEN, Qing; ZHANG, Hong; DAVIS, Timothy; DARMOHUSODO, Vincent; WONG, Melissa; SELCHAU, Victor
Patent: WO2013/25560 A1, 2013 ;
反应条件
1: trichlorophosphate
2: ammonia / isopropyl alcohol
3: sodium hydroxide / ethanol
View Scheme
参考文献
SENOMYX, INC.; TACHDJIAN, Catherine; TANG, Xiao Qing; KARANEWSKY, Donald S.; SERVANT, Guy; LI, Xiaodong; ZHANG, Feng; CHEN, Qing; ZHANG, Hong; DAVIS, Timothy; DARMOHUSODO, Vincent; WONG, Melissa; SELCHAU, Victor
Patent: WO2013/25560 A1, 2013 ;
