3-氯-1,2-苯代异噻唑合成路线 （共 24 条）
参考文献
Vitali,T. et al.
Farmaco, Edizione Scientifica, 1968 , vol. 23, p. 1081 - 1096
反应条件
hydrogenchloride in water; isopropyl alcohol; toluene; tert-butyl alcohol
参考文献
US5935960 A1, ;
US 5935960 A
参考文献
US4487773 A1, ;
US 4487773 A
反应条件
pyridine T=115 - 119°C; 25 h; Inert atmosphere; TemperatureSolvent;
参考文献
Organic Process Research and Development, , vol. 3, # 2 p. 126 - 130
反应条件
ammonia in formamide T=130°C; 0.75 h;
参考文献
Golec, Julian M. C.; Scrowston, Richard M.
Journal of Chemical Research, Miniprint, 1988 , # 1 p. 326 - 345
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
参考文献
Mead Johnson and Company
Patent: US4487773 A1, 1984 ;
US 4487773 A
反应条件
sulfuric acid; potassium nitrate
参考文献
Vitali,T. et al.
Farmaco, Edizione Scientifica, 1973 , vol. 28, p. 8 - 18
反应条件
1: 56.4 percent / 12 h / 120 °C 2: 84.9 percent / K2CO3, KI / dimethylformamide / 7 h / 90 - 100 °C View Scheme
参考文献
Ishizumi; Kojima; Antoku; Saji; Yoshigi
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 12 p. 2139 - 2151
