R(-)-gamma-乙烯基-gamma-氨基丁酸合成路线 （共 7 条）
反应条件
trimethylsilyl iodide in dichloromethane
a) 0 deg C, 4 h, b) room temperature, 8 h; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Wei, Zhong-Yong; Knaus, Edward E.
Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1586 - 1588
反应条件
potassium hydroxide in water; isopropyl alcohol
24 h; Heating;
参考文献
Wei, Zhong-Yong; Knaus, Edward E.
Tetrahedron, 1994 , vol. 50, # 19 p. 5569 - 5578
反应条件
1: 77 percent / H2 / Raney nickel / tetrahydrofuran / 24 h / 90 °C / 34200 - 38000 Torr
2: p-TsOH / methanol / 20 °C
3: imidazole; Ph3P; I2 / toluene / Heating
4: aq. HCl; AcOH
View Scheme
参考文献
Dagoneau; Tomassini; Denis; Vallee
Synthesis, 2001 , # 1 p. 150 - 154
反应条件
1: p-TsOH / methanol / 20 °C
2: imidazole; Ph3P; I2 / toluene / Heating
3: aq. HCl; AcOH
View Scheme
参考文献
Dagoneau; Tomassini; Denis; Vallee
Synthesis, 2001 , # 1 p. 150 - 154
反应条件
1: sodium periodate / H2O; methanol / 4 h
2: 1,2-dichloro-benzene / 4 h / Heating
3: 91 percent / potassium hydroxide / H2O; propan-2-ol / 24 h / Heating
View Scheme
参考文献
Wei, Zhong-Yong; Knaus, Edward E.
Tetrahedron, 1994 , vol. 50, # 19 p. 5569 - 5578
反应条件
1: 89 percent / magnesium / methanol / 4 h, 0 degC, 8 h, 25 degC
2: sodium periodate / H2O; methanol / 4 h
3: 1,2-dichloro-benzene / 4 h / Heating
4: 91 percent / potassium hydroxide / H2O; propan-2-ol / 24 h / Heating
View Scheme
参考文献
Wei, Zhong-Yong; Knaus, Edward E.
Tetrahedron, 1994 , vol. 50, # 19 p. 5569 - 5578
反应条件
1: 32 percent / benzene / 24 h / Heating
2: 80 percent / Ba(OH)2*H2O / H2O; propan-2-ol / 12 h / Heating
View Scheme
参考文献
Wei, Z. Y.; Knaus, Edward E.
Organic Preparations and Procedures International, 1994 , vol. 26, # 5 p. 567 - 570
