6-甲基-5-氧代-4,5-二氢吡嗪-2-羧酸甲酯合成路线 （共 6 条）
反应条件
N,N-dimethyl-formamide; trichlorophosphate 2 h; Heating;
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
thionyl chloride
2 h; Heating;
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 78 percent / conc. HCl / 4 h / Heating
2: 75 percent / SOCl2 / 2 h / Heating
View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 77 percent / nitrobenzene / 3 h / 170 - 180 °C
2: 33 percent / 10percent NaOH / 3 h / Heating
3: 75 percent / SOCl2 / 2 h / Heating
View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 33 percent / 10percent NaOH / 3 h / Heating
2: 75 percent / SOCl2 / 2 h / Heating
View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 77 percent / POCl3, DMF / 2 h / Heating
2: 9 percent / MCPBA / 1,2-dichloro-ethane / 39 h / 65 °C
3: 67 percent / K2CO3 / H2O / 2 h / Ambient temperature
4: 30 percent / 1 N NaOH / 2 h / Heating
View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
