5-溴-2-嘧啶甲酸乙酯合成路线 （共 10 条）
反应条件
thionyl chloride T=20°C; 18 h;
参考文献
OSLO UNIVERSITY HOSPITAL HF; HOLSWORTH, Daniel; WAALER, Jo; MACHON, Ondrej; KRAUSS, Stefan; VORONKOV, Andrey Edward; GOLDING, Louise
Patent: WO2012/76898 A1, 2012 ;
Location in patent: Page/Page column 58 ;
WO 2012/076898 A1
反应条件
1: bromo-difluoroacetic acid,ethyl ester With copper in dimethyl sulfoxide T=20°C; 1 h; 2: 2,5-dibromo-pyridine T=20°C; 15 h;
参考文献
DOW AGROSCIENCES LLC; GUSTAFSON, Gary, D.; HOEKSTRA, William, J.; LOSO, Michael, R.; YATES, Christopher, M.
Patent: WO2014/43376 A1, 2014 ;
Location in patent: Page/Page column 46; 47 ;
反应条件
1: in toluene T=80°C; 18 h; 2: With sodium hydrogencarbonate in ethyl acetate
参考文献
US2010/41642 A1, ;
Page/Page column 25 ;
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine in N,N-dimethyl-formamide T=50°C; P=1551.4 Torr;
参考文献
Chambers; Marfat
Synthetic Communications, 1997 , vol. 27, # 3 p. 515 - 520
反应条件
toluene-4-sulfonic acid 24 h; Reflux;
参考文献
Martin, Thibaut; Laguerre, Claire; Hoarau, Christophe; Marsais, Francis
Organic Letters, 2009 , vol. 11, # 16 p. 3690 - 3693
反应条件
1: KMnO4, H2O / 6 h / 100 °C 2: 1.) SOCl2 / 1.) reflux, 2 h, 2.) toluene, reflux, 2 h View Scheme
参考文献
Heterocycles, , vol. 15, # 1 p. 213 - 223
反应条件
1: With sodium tetrahydroborate in methanol T=20 - 70°C; 0.833333 h; 2: With hydrogenchloride in water pH=7;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ROBL, Jeffrey A.; LI, Jun; KENNEDY, Lawrence J.; WALKER, Steven J.; WANG, Haixia; WASHBURN, William N.; AHMAD, Saleem; NGU, Khehyong
Patent: WO2012/149236 A1, 2012 ;
Location in patent: Page/Page column 162 ;
WO 2012/149236 A1
反应条件
sodium in ethanol 3 h; Reflux;
参考文献
OSLO UNIVERSITY HOSPITAL HF; HOLSWORTH, Daniel; WAALER, Jo; MACHON, Ondrej; KRAUSS, Stefan; VORONKOV, Andrey Edward; GOLDING, Louise
Patent: WO2012/76898 A1, 2012 ;
Location in patent: Page/Page column 58 ;
WO 2012/076898 A1
反应条件
1: 47 percent / NaH / toluene
2: aq. 47percent HBr / 0.33 h / Heating
3: 67 percent / acetic anhydride
View Scheme
参考文献
Sanders, Georgine M.; Dijk, Marinus van; Plas, Henk C. van der
Heterocycles, 1981 , vol. 15, # 1 p. 213 - 223
反应条件
hydrazine in ethanol
T=90°C; 1.16667 h;
参考文献
LOCUS PHARMACEUTICALS, INC.
Patent: US2010/41642 A1, 2010 ;
Location in patent: Page/Page column 25 ;
