4,5-二甲氧基-2-甲基苯甲醛合成路线 （共 26 条）
反应条件
1: 100 percent / PCl5 / CCl4 2: 60 percent / 550 °C / 0.08 Torr 3: 38 percent / dimethylsulfoxide View Scheme
参考文献
Schiess, Peter; Rutschmann, Suzanne; Toan, Van Vien
Tetrahedron Letters, 1982 , vol. 23, # 36 p. 3669 - 3672
反应条件
1: 85.6 percent / methanol / 18 h / Ambient temperature 2: 1) DMSO, MeOH, 85 deg C, 3.5 h, 2) DMSO, a) 125 deg C, 1.25 h, b) 115 deg C, 1.5 View Scheme
参考文献
Manchand, Percy S.; Rosen, Perry; Belica, Peter S.; Oliva, Gloria V.; Perrotta, Agostino V.; Wong, Harry S.
Journal of Organic Chemistry, 1992 , vol. 57, # 13 p. 3531 - 3535
反应条件
1: 76.2 percent / perbenzoic acid / CH2Cl2 / 3 h / Heating 2: 76.44 percent / K2CO3 / acetone / 72 h / 75 °C / sealed tube View Scheme
参考文献
Kozlova, I. V.; Obol'nikova, E. A.; Chupina, L. N.; Bekker, A. R.; Samokhvalov, G. I.
Journal of Organic Chemistry USSR (English Translation), 1981 , p. 296 - 299
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 351 - 354
反应条件
trichlorophosphate
T=90 - 95°C; Vilsmeier formylation; Inert atmosphere;
参考文献
Le, Thanh Nguyen; Cho, Won-Jea
Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 7 p. 1026 - 1029
反应条件
tin(IV) chloride in dichloromethane
参考文献
ICI Pharma; Imperial Chemical Industries PLC
Patent: US5219848 A1, 1993 ;
反应条件
tin(IV) chloride in 1,2-dichloro-ethane
1.) ice-bath, 30 min, 2.) ice-bath temperature->room temperature, 24 h;
参考文献
Abou-Teim, Omar; Jansen, Robert B.; McOmie, John F. W.; Perry, David H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1841 - 1846
反应条件
sodium hydroxide in ethanol
3 h; Heating;
参考文献
Kozlova, I. V.; Obol'nikova, E. A.; Chupina, L. N.; Bekker, A. R.; Samokhvalov, G. I.
Journal of Organic Chemistry USSR (English Translation), 1981 , p. 296 - 299
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 351 - 354
反应条件
1: CuCl / dimethylformamide; methanol / 4.5 h / Heating
View Scheme
参考文献
Manchand, Percy S.; Rosen, Perry; Belica, Peter S.; Oliva, Gloria V.; Perrotta, Agostino V.; Wong, Harry S.
Journal of Organic Chemistry, 1992 , vol. 57, # 13 p. 3531 - 3535
反应条件
1: 90 percent / Br2 / CCl4 / Ambient temperature
2: 1) t-BuLi / 1) THF, pentane, 45 s, -78 deg C 2) THF a) 5 min, -78 deg C b) 2 h, r.t.
View Scheme
参考文献
Charlton; Koh; Plourde
Canadian Journal of Chemistry, 1990 , vol. 68, # 11 p. 2028 - 2032
反应条件
1: 45.2 percent / TiCl4 / CH2Cl2 / 3 h / 20 °C
2: 73.7 percent / 30percent NaOH / ethanol / 3 h / Heating
View Scheme
参考文献
Kozlova, I. V.; Obol'nikova, E. A.; Chupina, L. N.; Bekker, A. R.; Samokhvalov, G. I.
Journal of Organic Chemistry USSR (English Translation), 1981 , p. 296 - 299
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 351 - 354
