2,3-二氢-1H-吡咯并[1,2-A]苯并咪唑合成路线 （共 35 条）
反应条件
1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C
1.2: 84 percent / tetrahydrofuran / Heating
2.1: 70 percent / [RhCl(cis-cyclooctene)2]2; tricyclohexylphosphine / toluene / 20 h / 180 °C
View Scheme
参考文献
Tan; Bergman; Ellman
Journal of the American Chemical Society, 2001 , vol. 123, # 11 p. 2685 - 2686
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran; N,N-dimethyl-formamide
Mitsunobu reaction; 2 h;
参考文献
Indusegaram, Sutharsiny; Katsifis, Andrew G.; Ridley, Damon D.; Vonwiller, Simone C.
Australian Journal of Chemistry, 2003 , vol. 56, # 8 p. 819 - 827
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; dacarbazine; Wang resin in dichloromethane
T=20°C; 48 h;
2: With 2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in toluene
4.5 h; Heating;
参考文献
Allin, Steven M.; Bowman, W. Russell; Karim, Rehana; Rahman, Shahzad S.
Tetrahedron, 2006 , vol. 62, # 18 p. 4306 - 4316
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in toluene
7 h; Heating;
参考文献
Allin, Steven M.; Bowman, W. Russell; Karim, Rehana; Rahman, Shahzad S.
Tetrahedron, 2006 , vol. 62, # 18 p. 4306 - 4316
反应条件
1: 91 percent / iron powder, conc. hydrochloric acid / aq. ethanol
2: 29 percent / hydrogen / rhodium(II) acetate dimer, triphenylphosphine / ethyl acetate / 20 h / 70 °C / 20685.9 Torr
View Scheme
参考文献
Anastasiou, Despina; Campi, Eva M.; Chaouk, Hassan; Jackson, W. Roy
Tetrahedron, 1992 , vol. 48, # 36 p. 7467 - 7478
反应条件
1: 88 percent / Heating
2: 91 percent / iron powder, conc. hydrochloric acid / aq. ethanol
3: 29 percent / hydrogen / rhodium(II) acetate dimer, triphenylphosphine / ethyl acetate / 20 h / 70 °C / 20685.9 Torr
View Scheme
参考文献
Anastasiou, Despina; Campi, Eva M.; Chaouk, Hassan; Jackson, W. Roy
Tetrahedron, 1992 , vol. 48, # 36 p. 7467 - 7478
反应条件
potassium carbonate in water
T=20°C;
参考文献
Tomilov, Yury V.; Platonov, Dmitry N.; Frumkin, Aleksandr E.; Lipilin, Dmitry L.; Salikov, Rinat F.
Tetrahedron Letters, 2010 , vol. 51, # 39 p. 5120 - 5123
反应条件
1: With potassium hydroxide in ethanol
Alkylation; 0.75 h; Heating;
2: With lithium diisopropyl amide in tetrahydrofuran
T=-78 - 20°C; Cyclization; 3.5 h;
参考文献
McClure, James R.; Custer, John H.; Schwarz, H. Dean; Lill, Deborah A.
Synlett, 2000 , # 5 p. 710 - 712
反应条件
1: boron trifluoride diethyl etherate / dichloromethane / 20 °C / Inert atmosphere
2: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere; Reflux
View Scheme
参考文献
Bastug, Gulluzar; Eviolitte, Christophe; Marko, Istvan E.
Organic Letters, 2012 , vol. 14, # 13 p. 3502 - 3505
反应条件
1: 1.) NaH / 1) acetonitrile, reflux, 1 h; 2) acetonitrile, reflux, 2 h
2: 49 percent / Bu3SnH, AIBN / toluene / 6 h / Heating
View Scheme
参考文献
Aldabbagh, Fawaz; Bowman, W. Russell
Tetrahedron, 1999 , vol. 55, # 13 p. 4109 - 4122
