(3aR,4aS,7S,8aS)-7-溴-1,3,3a,4a,5,6,7,8,8a,9-十氢-4a,8,8-三甲基呋喃并[3,4-b][1]苯并氧杂卓合成路线 （共 13 条）
→
77249-86-6(3aR,4aS,7S,8aS)-7-溴-1,3,3a,4a,5,6,7,8,8a,9-十氢-4a,8,8-三甲基呋喃并[3,4-b][1]苯并氧杂卓
反应条件
1: p-TsOH.H2O / methanol / 4 h / Ambient temperature
2: pyridine
3: LiBr.H2O / dimethylformamide / 2.5 h / 80 - 90 °C
5: 50 percent aq. K2CO3 / methanol / 0.25 h / Ambient temperature
View Scheme
参考文献
Tanaka, Akira; Suzuki, Masanobu; Yamashita, Kyohei
Agricultural and Biological Chemistry, 1986 , vol. 50, # 4 p. 1069 - 1072
→
77249-86-6(3aR,4aS,7S,8aS)-7-溴-1,3,3a,4a,5,6,7,8,8a,9-十氢-4a,8,8-三甲基呋喃并[3,4-b][1]苯并氧杂卓
反应条件
1: LiBr.H2O / dimethylformamide / 2.5 h / 80 - 90 °C
3: 50 percent aq. K2CO3 / methanol / 0.25 h / Ambient temperature
View Scheme
参考文献
Tanaka, Akira; Suzuki, Masanobu; Yamashita, Kyohei
Agricultural and Biological Chemistry, 1986 , vol. 50, # 4 p. 1069 - 1072
→
77249-86-6(3aR,4aS,7S,8aS)-7-溴-1,3,3a,4a,5,6,7,8,8a,9-十氢-4a,8,8-三甲基呋喃并[3,4-b][1]苯并氧杂卓
反应条件
1: 1.) n-BuLi / 1.)THF; 2.)THF, room temperature
2: n-BuLi / tetrahydrofuran / -65 °C
3: n-BuLi / tetrahydrofuran / 1 h / -70 - -65 °C
4: p-TsOH.H2O / methanol / 4 h / Ambient temperature
5: pyridine
6: LiBr.H2O / dimethylformamide / 2.5 h / 80 - 90 °C
8: 50 percent aq. K2CO3 / methanol / 0.25 h / Ambient temperature
View Scheme
参考文献
Tanaka, Akira; Suzuki, Masanobu; Yamashita, Kyohei
Agricultural and Biological Chemistry, 1986 , vol. 50, # 4 p. 1069 - 1072
