1.1: K2CO3; pyridine / 1 h / 20 °C 1.2: 85 percent / 4 h / 90 °C 2.1: 98 percent / NaBH4 / methanol; tetrahydrofuran / 0.5 h / 0 °C 3.1: PPh3; I2; imidazole / tetrahydrofuran / 0.5 h / 20 °C 4.1: dimethylformamide / 0.5 h / 40 °C 5.1: 98 percent / H2 / Pd/C / dioxane / 12 h / 20 °C 6.1: CoCl2*6H2O; NaBH4 / methanol / 0 °C 6.2: i-Pr2NEt; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / CH2Cl2; dimethylformamide / 0 - 20 °C 7.1: 75 percent / N-bromosuccinimide / acetonitrile / 2 h / 0 °C 8.1: aq. LiOH / methanol; tetrahydrofuran / 5 h / 0 °C 9.1: TFA / CH2Cl2 / 0 °C 10.1: i-Pr2NEt; PyBOP / CH2Cl2; dimethylformamide / 25 h / 0 - 20 °C 11.1: 43 percent / BBr3; thioanisole / CH2Cl2 / 1 h / 0 - 20 °C View Scheme