1,1'-亚甲基二[5-氧代-L-脯氨酸]二甲酯合成路线 （共 1 条）
反应条件
1: 81 percent / hydrazine hydrate / ethanol / 10 h / Heating
2: conc. hydrochloric acid, sodium nitrite / H2O; CHCl3 / -5 °C
3: CHCl3 / 50 °C
4: 70 percent / conc. hydrochloric acid / CHCl3
5: conc. hydrochloric acid, sodium nitrite / H2O / -6 °C
6: 70 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating
View Scheme
参考文献
Miquel, Christian; Pigache, Pierre; Rigo, Benoit; Kolocouris, Nicolas
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1447 - 1453
