1-环丙基哌嗪-4-羧酸叔丁酯合成路线 （共 6 条）
反应条件
hydrogenchloride in 1,4-dioxane T=20°C;
参考文献
VITAE PHARMACEUTICALS, INC.
Patent: WO2009/111028 A1, 2009 ;
Location in patent: Page/Page column 69 ;
WO 2009/111028 A1
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 3 h;
参考文献
US2008/153812 A1, ;
Page/Page column 117 ;
US 20080153812 A1
反应条件
1: With sodium hydroxide; sodium cyanoborohydride; acetic acid in methanol
T=60°C; 5 h;
2: With water in methanol
0.0833333 h;
3: With sodium hydroxide in methanol; water
0.25 h;
参考文献
Allison, Brett D.; Carruthers, Nicholas I.; Grice, Cheryl A.; Letavic, Michael A.
Patent: US2007/66821 A1, 2007 ;
Location in patent: Page/Page column 8 ;
US 20070066821 A1
反应条件
[2,2']bipyridinyl; oxygen; copper diacetate; sodium carbonate in 1,2-dichloro-ethane
T=70°C; Chan-Lam reaction;
参考文献
Benard, Sebastien; Neuville, Luc; Zhu, Jieping
Chemical Communications, 2010 , vol. 46, # 19 p. 3393 - 3395
反应条件
sodium cyanoborohydride; acetic acid in tetrahydrofuran; methanol
T=63°C; 16 h;
参考文献
Zaragoza, Florencio; Stephensen, Henrik; Knudsen, Sanne M.; Pridal, Lone; Wulff, Birgitte S.; Rimvall, Karin
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2833 - 2838
反应条件
hydrogenchloride; sodium hydroxide in ethyl acetate
参考文献
ICI Americas Inc.
Patent: US4247549 A1, 1981 ;
