4-(吡啶-2-基)哌嗪-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
1: With trifluoroacetic acid in dichloromethane T=30°C; 1 h; 2: With sodium hydroxide in dichloromethane; water pH=9;
参考文献
BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael
Patent: WO2011/28947 A2, 2011 ;
Location in patent: Page/Page column 50; 51 ;
WO 2011/028947 A1
反应条件
N-iodo-succinimide; dibenzoyl peroxide in tetrachloromethane T=20°C;
参考文献
WO2008/62276 A2, ;
Page/Page column 50 ;
WO 2008/062276 A2
反应条件
Amberlyst® A21 in neat (no solvent)
T=20°C; 0.0333333 h; Green chemistry;
参考文献
Tekale, Sunil U.; Kauthale, Sushama S.; Pawar, Rajendra P.
Journal of the Chilean Chemical Society, 2013 , vol. 58, # 1 p. 1619 - 1623
反应条件
sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene
T=100°C; Inert atmosphere;
参考文献
BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael
Patent: WO2011/28947 A2, 2011 ;
Location in patent: Page/Page column 50-51 ;
WO 2011/028947 A1
反应条件
sodium t-butanolate; palladium diacetate in toluene
T=80°C; Buchwald-Hartwig amination; 8 h;
参考文献
Reddy, Ch. Venkat; Kingston, Jesudoss V.; Verkade, John G.
Journal of Organic Chemistry, 2008 , vol. 73, # 8 p. 3047 - 3062
反应条件
[(1,3-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazole-2-ylidene)PdCl2(triethylamine)]; potassium tert-butylate in ethylene glycol dimethyl ether
T=20°C; Buchwald-Hartwig Coupling; 24 h; Sealed tube;
参考文献
Guest, Daniel; Chen, Ming-Tsz; Tizzard, Graham J.; Coles, Simon J.; Turner, Michael Lewis; Navarro, Oscar
European Journal of Inorganic Chemistry, 2014 , # 13 p. 2200 - 2203
