叔丁基-4-(2-羟乙基)哌嗪-1-羧酸酯合成路线 （共 12 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-78°C; Swern oxidation; 0.5 h; Inert atmosphere;
2: With triethylamine in dichloromethane
T=-78 - 20°C; Swern oxidation; 1.5 h; Inert atmosphere;
参考文献
Johnson, Mark; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5826 - 5840
反应条件
1.1: iodine; triphenylphosphine / dichloromethane / 20 h
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
2.2: 6 h / 110 °C
3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
Wagner, Eva; Wittmann, Hans-Joachim; Elz, Sigurd; Strasser, Andrea
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6274 - 6280
