2-甲基-2-丙基4-(4-氯苄基)-1-哌嗪羧酸酯合成路线 (共 3 条)
反应条件
trifluoroacetic acid in dichloromethane Ambient temperature;
参考文献
Bourrain, Sylvie; Collins, Ian; Neduvelil, Joseph G.; Rowley, Michael; Leeson, Paul D.; Patel, Smita; Patel, Shil; Emms, Frances; Marwood, Rosemarie; Chapman, Kerry L.; Fletcher, Alan E.; Showell, Graham A.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 10 p. 1731 - 1743
反应条件
potassium carbonate in ethanol
参考文献
Merck, Sharp and Dohme, Ltd.
Patent: US5684006 A1, 1997 ;
US 5684006 A
反应条件
sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane
T=20°C; 6 h; Inert atmosphere;
参考文献
Flanagan, Jack U.; Atwell, Graham J.; Heinrich, Daniel M.; Brooke, Darby G.; Silva, Shevan; Rigoreau, Laurent J.M.; Trivier, Elisabeth; Turnbull, Andrew P.; Raynham, Tony; Jamieson, Stephen M.F.; Denny, William A.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 3 p. 967 - 977