hydrogen bromide; acetic anhydride 72 h; Heating;

1: methanol 2: H2O/KOH / ethanol / 16 h / Ambient temperature 3: hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 10 h / Heating View Scheme

1: KOAc/Ac2O / 2 h / Heating 2: 250 - 260 °C / 10 Torr 3: methanol 4: H2O/KOH / ethanol / 16 h / Ambient temperature 5: hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 10 h / Heating View Scheme

1: H2O/KOH / ethanol / 16 h / Ambient temperature 2: hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 10 h / Heating View Scheme

potassium hydroxide in diethylene glycol Heating;

(i) NaH, 1,2-dimethoxyethane, (ii) /BRN= 969135/; Multistep reaction;

1: 91 percent / concn H2SO4 / 1,2-dichloro-ethane / 20 h / Heating 2: 92 percent / BF3*OEt2 / Ambient temperature 3: 94 percent / NaOMe / methanol / 2 h / Heating 4: 92 percent / SF4 / 24 h / Ambient temperature 5: 96 percent / H2O/KOH / ethanol / 16 h / Ambient temperature 6: 90 percent / diethyl ether; hexane / 2 h / Heating 7: 77 percent / m-chloroperbenzoic acid / CH2Cl2 / 72 h / Ambient temperature 8: 93 percent / NaOMe / methanol / 2 h / Heating 9: 81 percent / SF4 / 24 h / Ambient temperature View Scheme

1: 91 percent / concn H2SO4 / 1,2-dichloro-ethane / 20 h / Heating 2: 92 percent / BF3*OEt2 / Ambient temperature 3: 94 percent / NaOMe / methanol / 2 h / Heating View Scheme

1: 91 percent / concn H2SO4 / 1,2-dichloro-ethane / 20 h / Heating 2: 92 percent / BF3*OEt2 / Ambient temperature 3: 94 percent / NaOMe / methanol / 2 h / Heating 4: 92 percent / SF4 / 24 h / Ambient temperature 5: 96 percent / H2O/KOH / ethanol / 16 h / Ambient temperature 6: thionyl chloride View Scheme

1: 83 percent / 55percent aq. HI, acetic anhydride / 120 h / Heating 2: 92 percent / H2SO4 / CH2Cl2 / 24 h / Heating 3: iodine monochloride / CCl4 / 48 h / Ambient temperature 4: 91 percent / aq. KOH / ethanol 5: 45 percent Spectr. / sulfur tetrafluoride / 48 h / 150 °C View Scheme