4-溴-2,6-二氟苯甲酸甲酯合成路线 （共 12 条）
反应条件
sulfuric acid Reflux;
参考文献
MERCK SHARP and DOHME CORP; COBURN, Craig, A.; ROSENBLUM, Stuart, B.; KOZLOWSKI, Joseph, A.; SOLL, Richard; WU, Hao; HU, Bin; ZHONG, Bin; WANG, Dahai; SHEN, Changmao; SUN, Fei
Patent: WO2012/125926 A2, 2012 ;
Location in patent: Page/Page column 82-83 ;
反应条件
1: 4-bromo-2,6-difluorobenzoic acid With thionyl chloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 2.5 h; 2: methanol in dichloromethane T=0°C; 0.5 h;
参考文献
WO2007/131991 A1, ;
Page/Page column 117 ;
反应条件
thionyl chloride in methanol 3 h; Reflux;
参考文献
MERCK SHARP and DOHME CORP.; COBURN, Craig, A.; ROSENBLUM, Stuart, B.; KOZLOWSKI, Joseph, A.; SOLL, Richard; WU, Hao; HU, Bin; ZHONG, Bin; WANG, Dahai; SHEN, Changmao; SUN, Fei
Patent: WO2012/122716 A1, 2012 ;
Location in patent: Page/Page column 101-102 ;
反应条件
in methanol; diethyl ether; dichloromethane T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: US2010/305133 A1, 2010 ;
Location in patent: Page/Page column 34 ;
反应条件
potassium carbonate in acetone T=50°C;
参考文献
Kelly, Michael G.; Kincaid, John; Duncton, Matthew; Sahasrabudhe, Kiran; Janagani, Satyanarayana; Upasani, Ravindra B.; Wu, Guoxian; Fang, Yunfeng; Wei, Zhi-Liang
Patent: US2006/194801 A1, 2006 ;
Location in patent: Page/Page column 45-46 ;
反应条件
potassium carbonate in acetone T=50°C; 16 h;
参考文献
WO2010/120854 A1, ;
Page/Page column 72 ;
WO 2010/120854 A1
反应条件
in dichloromethane; N,N-dimethyl-formamide T=0°C; 0.5 h;
参考文献
WO2007/138072 A2, ;
Page/Page column 101 ;
反应条件
1.1: lithium diisopropyl amide; N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 2.5 h / -60 - -50 °C 1.2: pH 2 - 3 2.1: sulfuric acid / Reflux View Scheme
反应条件
1.1: magnesium sulfate; sodium hydride / dimethyl sulfoxide / 0.5 h 1.2: 48 h 2.1: iron; acetic acid / water; ethanol / 3 h / |Reflux 3.1: potassium carbonate / ethanol / 0.5 h / 20 °C View Scheme
参考文献
CROWN BIOSCIENCE INC. (TAICANG); ZHONG, Boyu; SHIH, Chuan; YUAN, Hongbin; ZHOU, Feng
Patent: WO2014/32498 A1, 2014 ;
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane T=70°C; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28952 A1, 2012 ;
Location in patent: Page/Page column 17 ;
