4-溴-2,6-二氟苯甲酸甲酯合成路线 （共 12 条）
反应条件
1: nitromethane With sodium hydride; magnesium sulfate in dimethyl sulfoxide
T=20°C; 0.25 h;
2: methyl 4-bromo-2,6-difluorobenzoate in dimethyl sulfoxide
T=20°C; 72 h;
3: With hydrogenchloride; water in dimethyl sulfoxide
参考文献
GALAPAGOS N.V.
Patent: WO2007/138072 A2, 2007 ;
Location in patent: Page/Page column 101 ;
反应条件
1: nitromethane With sodium hydride; magnesium sulfate in dimethyl sulfoxide
0.5 h;
2: methyl 4-bromo-2,6-difluorobenzoate in dimethyl sulfoxide
48 h;
参考文献
CROWN BIOSCIENCE INC. (TAICANG); ZHONG, Boyu; SHIH, Chuan; YUAN, Hongbin; ZHOU, Feng
Patent: WO2014/32498 A1, 2014 ;
Location in patent: Page/Page column 13 ;
