乙基 5-溴-2-(三氟甲氧基)苯甲酸合成路线 （共 2 条）
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With (2,2,6,6-tetramethylpiperidyl)2Mn*2MgCl2*4LiCl in tetrahydrofuran T=25°C; 10 h; Inert atmosphere; 2: [(Cyanocarbonyl)oxy]ethane in tetrahydrofuran T=0 - 25°C; Inert atmosphere; chemospecific reaction;
参考文献
Wunderlich, Stefan H.; Kienle, Marcel; Knochel, Paul
Angewandte Chemie, International Edition, 2009 , vol. 48, # 39 p. 7256 - 7260
Angewandte Chemie, 2009 , vol. 121, # 39 p. 7392 - 7396
反应条件
1: With sodium hydroxide in ethanol T=85°C; 18 h; Inert atmosphere; 2: With hydrogenchloride in dichloromethane; water pH=4;
参考文献
Gilead Palo Alto, Inc.
Patent: US2011/21521 A1, 2011 ;
Location in patent: Page/Page column 56; 57 ;
