2-氨基-5-碘苯甲酸甲酯合成路线 （共 15 条）
反应条件
iodine cloride; acetic acid 24 h;
参考文献
PHARMACOSTECH CO., LTD.; KIM, Jae Won; CHA, Young Gwan; RYU, Hyung Chul; KIM, Sun Joo; KIM, Sang Hyun; JEON, Tae Hong
Patent: WO2010/67912 A1, 2010 ;
Location in patent: Page/Page column 10-11 ;
反应条件
4-(N,N-dimethlyamino)pyridine in methanol T=60°C; 3 h;
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
WO2013/116786 A1, ;
Page/Page column 18 ;
反应条件
hydrogenchloride 24 h; Heating;
参考文献
Takalo, Harri; Kankare, Jouko; Haenninen, Elina
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 7 p. 448 - 454
反应条件
potassium carbonate in methanol
反应条件
4-(N,N-dimethlyamino)pyridine T=20 - 80°C; 4 h;
参考文献
WO2005/28474 A2, ;
Page/Page column 207 ;
WO 2005/028474 A2
反应条件
1: 92 percent / dioxane / 60 °C 2: 97 percent / 4-(dimethylamino)pyridine / methanol / 3 h / 60 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2136 - 2145
反应条件
triethylamine in 1,4-dioxane; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1270577 A1, 2003 ;
反应条件
1: With trifluoroacetic acid; sodium nitrite T=0°C; 0.666667 h; 2: With sodium azide in water 3 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; SCARBOROUGH, Carroll
Patent: WO2008/86226 A2, 2008 ;
Location in patent: Page/Page column 112 ;
WO 2008/086226 A2
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in methanol T=70°C; 8 h; Inert atmosphere;
参考文献
Adepu, Raju; Sunke, Rajnikanth; Meda, Chandana L. T.; Rambabu; Krishna, G. Rama; Reddy, C. Malla; Deora, Girdhar Singh; Parsa, Kishore V. L.; Pal, Manojit
Chemical Communications, 2013 , vol. 49, # 2 p. 190 - 192
