2-氨基-5-碘苯甲酸甲酯合成路线 （共 15 条）
反应条件
1: 70 percent / H2O; acetic acid / Heating 2: 60.5 g / aq. NaOH / methanol / 1 h / Heating 3: 89 percent / POCl3, N,N-dimethylaniline / 2 h / 150 °C View Scheme
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
acetic acid; diethylamine T=150°C; 2 h; Product distribution / selectivity;
参考文献
Mitsubishi Gas Chemical Company, Inc.
Patent: EP1997812 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
1: 70 percent / H2O; acetic acid / Heating 2: 60.5 g / aq. NaOH / methanol / 1 h / Heating View Scheme
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
1: 70 percent / H2O; acetic acid / Heating 2: 60.5 g / aq. NaOH / methanol / 1 h / Heating 3: 89 percent / POCl3, N,N-dimethylaniline / 2 h / 150 °C 4: 96 percent / NaBH4 / CHCl3; ethanol / 1.) 0 deg C, 2.) room temperature, 1 h 5: 84 percent / potassium carbonate / butan-2-one / Heating View Scheme
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
diisobutylaluminium hydride in tetrahydrofuran; cyclohexane
T=-41 - 20°C; Inert atmosphere;
参考文献
Cronk, W. Cole; Mukhina, Olga A.; Kutateladze, Andrei G.
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1235 - 1246
