773837-37-9合成路线 （共 596 条）
反应条件
in 1,4-dioxane; water 2 h; Reflux;
参考文献
Cisneros, Jose A.; Bjoerklund, Emmelie; Gonzalez-Gil, Ines; Hu, Yanling; Canales, Angeles; Medrano, Francisco J.; Romero, Antonio; Ortega-Gutierrez, Silvia; Fowler, Christopher J.; Lopez-Rodriguez, Maria L.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 824 - 836
反应条件
copper(l) chloride Sandmeyer reaction;
参考文献
Gassmann, Joerg; Voss, Juergen
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2008 , vol. 63, # 11 p. 1291 - 1299
反应条件
in N,N-dimethyl-formamide T=20 - 25°C; Inert atmosphere;
参考文献
PFIZER INC.; BROWN, Matthew Frank; MARFAT, Anthony; MELNICK, Michael Joseph; REILLY, Usa
Patent: WO2011/45703 A2, 2011 ;
Location in patent: Page/Page column 40 ;
WO 2011/045703 A2
反应条件
water in ethanol T=50°C; 12 h;
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
Location in patent: Page/Page column 110-111 ;
WO 2012/119941 A1
反应条件
sodium hydroxide in water T=117°C; 17 h; Autoclave;
参考文献
RHODIA OPERATIONS; Buisine, Olivier
Patent: US2014/12033 A1, 2014 ;
Location in patent: Paragraph 0186 - 0191 ;
反应条件
in ethanol 16 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ABEYWARDANE, Asitha; HAO, Ming-Hong; TAYLOR, Steven, John
Patent: WO2010/19417 A2, 2010 ;
Location in patent: Page/Page column 25-27 ;
WO 2010/019417 A2
反应条件
1: 2-chloro-4-methyl-pyridine 1-oxide With dimethyl sulfate 2: sodium cyanide in water T=-15 - -7°C; Inert atmosphere;
参考文献
MERCK SHARP and DOHME CORP.; WOOD, Harold, B.; ADAMS, Alan, D.; SZEWCZYK, Jason, W.; ZHANG, Yong; YANG, Meng
Patent: WO2011/19538 A1, 2011 ;
Location in patent: Page/Page column 123-124 ;
WO 2011/019538 A1
反应条件
1: With potassium iodide in N,N-dimethyl-formamide T=120°C; 72 h; 2: With sodium hydrogencarbonate in N,N-dimethyl-formamide
参考文献
Pfizer Inc.
Patent: US2010/113465 A1, 2010 ;
Location in patent: Page/Page column 24 ;
US 20100113465 A1
反应条件
iodine in further solvent(s) byproducts: CNI; solvolysis in liq. I2;;
参考文献
Gmelin Handbook: Na: SVol.4, 4, page 1377 - 1379
反应条件
copper (I) cyanide T=20°C;
参考文献
, vol. 36, # 10 p. 573 - 574,2
