773837-37-9合成路线 （共 596 条）
反应条件
tetrabutylammomium bromide in dichloromethane; water T=50°C; 29 h;
参考文献
CORTICAL PTY LTD
Patent: WO2003/104178 A1, 2003 ;
Location in patent: Page 88 ;
反应条件
in dimethyl sulfoxide T=0 - 10°C; 2.25 h;
参考文献
HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian
Patent: WO2011/47156 A1, 2011 ;
Location in patent: Page/Page column 97-98 ;
WO 2011/047156 A1
反应条件
sulfuric acid; acetic acid in water T=85°C; Ritter reaction; 0.05 h;
参考文献
Brandt, Johan C.; Elmore, Simon C.; Robinson, Richard I.; Wirth, Thomas
Synlett, 2010 , # 20 art. no. D26910ST, p. 3099 - 3103
反应条件
in ethanol; water 1.5 h; Reflux;
参考文献
EXXONMOBIL RESEARCH AND ENGINEERING COMPANY; DAKKA, Jihad M.; MOZELESKI, Edmund J.; BAUGH, Lisa S.; BENITEZ, Frank, M.
Patent: WO2011/41349 A1, 2011 ;
Location in patent: Page/Page column 20 ;
反应条件
1: 5-chloro-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-phthalan With triphenylphosphine; nickel dichloride; zinc in acetonitrile 1.16667 h; Heating / reflux; 2: sodium cyanide in acetonitrile T=20°C; 15 h; Heating / reflux;
参考文献
ORION CORPORATION FERMION
Patent: WO2004/11450 A1, 2004 ;
Location in patent: Page 15, 16 ;
反应条件
N,N,N',N,-tetramethylethylenediamine; 1,5-bis-(diphenylphosphino)-pentane; palladium diacetate in 1,3,5-trimethyl-benzene 12 h; Inert atmosphereReflux;
参考文献
Duong, Adam; Maris, Thierry; Lebel, Olivier; Wuest, James D.
Journal of Organic Chemistry, 2011 , vol. 76, # 5 p. 1333 - 1341
反应条件
in 1,2-bis-(2-hydroxyethoxy)-ethane T=140°C;
参考文献
Louw, Stefan; Burger, Ben V.; Le Roux, Maritha; Van Wyk, Johannes H.
Journal of Natural Products, 2011 , vol. 74, # 6 p. 1364 - 1369
反应条件
tetrabutylammomium bromide in water; toluene T=20°C; chemoselective reaction;
参考文献
Patil, Shivaraj P.; Kanawade, Shrikant B.; Shinde, Madhukar P.; Toche, Raghunath B.
Indian Journal of Heterocyclic Chemistry, 2011 , vol. 21, # 1 p. 33 - 36
反应条件
1: With ammonium chloride in methanol; water T=20°C; Strecker amino acid synthesis; 24.3333 h; 2: With hydrogenchloride; water 72 h; Reflux;
参考文献
Nieto, Sonia; Sayago, Francisco J.; Laborda, Pedro; Soler, Tatiana; Cativiela, Carlos; Urriolabeitia, Esteban P.
Tetrahedron, 2011 , vol. 67, # 23 p. 4185 - 4191
反应条件
1: 4-bromo-2,6-dimethylbenzenamine With hydrogenchloride in water T=90°C; 1 h; 2: With sodium nitrite in water T=0°C; 3: sodium cyanide; copper (I) cyanide
参考文献
Diaz, Caroline Jean; Haffner, Curt Dale; Speake, Jason Daniel; Zhang, Cunyu; Mills, Wendy Yoon; Spearing, Paul Kenneth; Cowan, David John; Green, Gary Martin
Patent: US2010/222345 A1, 2010 ;
Location in patent: Page/Page column 96 ;
