773837-37-9合成路线 （共 596 条）
反应条件
in acetonitrile T=80°C; 16 h; Inert atmosphere;
参考文献
ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi
Patent: WO2013/149997 A1, 2013 ;
Location in patent: Page/Page column 55; 56 ;
反应条件
in dimethyl sulfoxide T=100°C; 2 h;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BENDELS, Stefanie; GRETHER, Uwe; KIMBARA, Atsushi; NETTEKOVEN, Matthias; ROEVER, Stephan; ROGERS-EVANS, Mark; SCHAFFTER, Ernst; SCHULZ-GASCH, Tanja
Patent: WO2014/86806 A1, 2014 ;
Location in patent: Page/Page column 49 ;
反应条件
in water T=0 - 20°C; 21 h; Industry scaleInert atmosphere; Product distribution / selectivity;
参考文献
Synergetica Changzhou Chemical Company
Patent: US2010/305330 A1, 2010 ;
Location in patent: Page/Page column 2-3 ;
反应条件
sodium tetrahydroborate in methanol; formamide
参考文献
Kwon, Tae Hoon; Yoon, Ik Hwan; Shin, Ji-Sun; Lee, Young Hun; Kwon, Bong Jin; Lee, Kyung-Tae; Lee, Yong Sup
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2571 - 2574
反应条件
in N,N-dimethyl-formamide 16 h; Inert atmosphereReflux;
参考文献
Ampac Fine Chemicals LLC
Patent: US2009/292122 A1, 2009 ;
Location in patent: Page/Page column 11 ;
反应条件
in N,N-dimethyl-formamide T=135°C;
参考文献
Sanofi Aventis
Patent: US2009/318473 A1, 2009 ;
Location in patent: Page/Page column 27 ;
反应条件
1: 3-methyl-pyridine 1-oxide With ethyl iodide in dichloromethane Reflux; 2: sodium cyanide in water T=50 - 60°C; 2 h;
参考文献
IRM LLC
Patent: WO2009/105717 A1, 2009 ;
Location in patent: Page/Page column 29 ;
WO 2009/105717 A1
反应条件
potassium carbonate in water T=50°C;
参考文献
RENOVIS, INC.
Patent: WO2009/11904 A1, 2009 ;
Location in patent: Page/Page column 56-57 ;
WO 2009/011904 A1
反应条件
in ethanol; water 3 h; Reflux;
参考文献
Pfizer Inc
Patent: US2009/298811 A1, 2009 ;
Location in patent: Page/Page column 58 ;
反应条件
in water; dimethyl sulfoxide T=100°C; 30 h;
参考文献
Kaneka Corporation
Patent: US6344569 B1, 2002 ;
Location in patent: Page column 13-14 ;
