773837-37-9合成路线 （共 596 条）
反应条件
1: 3-ethylpyridine N-oxide With ethyl iodide T=60°C; 1 h; 2: sodium cyanide in water T=50°C; 1 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; OTSUKI, Junko
Patent: WO2011/49220 A1, 2011 ;
Location in patent: Page/Page column 249 ;
反应条件
1: 3-ethylpyridine N-oxide; ethyl iodide T=60°C; 1 h; 2: sodium cyanide in water T=20°C;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; OTSUKI, Junko
Patent: WO2011/40629 A1, 2011 ;
Location in patent: Page/Page column 249-250 ;
反应条件
in dimethyl sulfoxide T=140 - 145°C; 3 h;
参考文献
Chinea, Kimberly; Vera, William J.; Sanchez, Jennifer; Banerjee, Ajoy K.
Organic Preparations and Procedures International, 2013 , vol. 45, # 4 p. 328 - 331
反应条件
copper (I) cyanide; lithium tert-butylate in 1,4-dioxane; m-xylene T=110°C; 5 h; Inert atmosphere; regioselective reaction;
参考文献
Do, Hien-Quang; Daugulis, Olafs
Organic Letters, 2010 , vol. 12, # 11 p. 2517 - 2519
反应条件
in acetone T=63°C; 3 h; Inert atmosphere;
参考文献
Rojas, Giovanni; Inci, Bora; Wei, Yuying; Wagener, Kenneth B.
Journal of the American Chemical Society, 2009 , vol. 131, # 47 p. 17376 - 17386
反应条件
in dimethyl sulfoxide T=20°C; 16 h;
参考文献
CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; TAYLOR, Alexander, M.; VASWANI, Rishi, G.
Patent: WO2013/184878 A1, 2013 ;
Location in patent: Paragraph 00194; 00195 ;
反应条件
acetic acid in methanol T=15 - 20°C; Inert atmosphere;
参考文献
Campos, Kevin R.; Klapars, Artis; Kohmura, Yoshinori; Pollard, David; Ishibashi, Hideaki; Kato, Shinji; Takezawa, Akihiro; Waldman, Jacob H.; Wallace, Debra J.; Chen, Cheng-Yi; Yasuda, Nobuyoshi
Organic Letters, 2011 , vol. 13, # 5 p. 1004 - 1007
反应条件
in water; acetonitrile Reflux;
参考文献
Zhao, Wenjun; Huang, Li; Guan, Yong; Wulff, William D.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 13 p. 3436 - 3441
Angew. Chem., 2014 , vol. 126, # 13 p. 3504 - 3509,6
反应条件
IR-120 H+ in water T=100°C; 48 h;
参考文献
Gallas, Katharina; Pototschnig, Gerit; Adanitsch, Florian; Stuetz, Arnold E.; Wrodnigg, Tanja M.
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1619 - 1629,11
参考文献
Istrati, Daniela; Parvulescu, Luminitza; Popescu, Angela; Mihaiescu, Dan; Andrei, Elena; Badea, Florin
Revue Roumaine de Chimie, 2009 , vol. 54, # 10 p. 847 - 850
