773837-37-9合成路线 （共 596 条）
反应条件
1: 1-(1,1-diphenylmethyl)azetidin-3-one; benzylamine With acetic acid in methanol T=20°C; 0.75 h; 2: sodium cyanide T=20°C; Heating / reflux;
参考文献
Pfizer Inc.
Patent: US2004/214837 A1, 2004 ;
Location in patent: Page 31 ;
US 20040214837 A1
反应条件
in methanol T=20°C; Heating / reflux;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/37823 A1, 2004 ;
Location in patent: Page 76 ;
WO 2004/037823 A1
反应条件
1: 4-trifluoromethyl-benzaldehyde With sodium hydrogensulfite in diethyl ether; water T=20°C; 2 h; 2: sodium cyanide in diethyl ether; water T=20°C;
参考文献
Xu, Qing; Xie, Yongli; Geng, Xiaohong; Chen, Peiran
Tetrahedron, 2010 , vol. 66, # 3 p. 624 - 630
反应条件
in N,N-dimethyl-formamide T=70°C; 4 h;
参考文献
Veitia, Maite Sylla-Iyarreta; Brun, Pierre Louis; Jorda, Pierre; Falguieres, Annie; Ferroud, Clotilde
Tetrahedron Asymmetry, 2009 , vol. 20, # 18 p. 2077 - 2089
反应条件
1: 4-bromo-benzaldehyde With (1R,2R)-cyclohexane-1,2-diylbis(2-azaethenyl-3-tert-butyl-2-hydroxybenzo-5-sulfonic acid) disodium salt; Manganese (II) acetate in methanol T=20°C; 0.5 h; 2: sodium cyanide in methanol T=20°C; 24 h; optical yield given as percent eeenantioselective reaction;
参考文献
Qu, Yanyang; Jing, Linhai; Wu, Zhiqing; Wu, Di; Zhou, Xiangge
Tetrahedron Asymmetry, 2010 , vol. 21, # 2 p. 187 - 190
反应条件
1: With ammonium chloride in methanol; water T=20°C; Strecker amino acid synthesis; 24.3333 h; 2: With hydrogenchloride; water 72 h; Reflux;
参考文献
Nieto, Sonia; Sayago, Francisco J.; Laborda, Pedro; Soler, Tatiana; Cativiela, Carlos; Urriolabeitia, Esteban P.
Tetrahedron, 2011 , vol. 67, # 23 p. 4185 - 4191
反应条件
1: 4-nitrobenzaldehdye With DOWER(R)50WX4 in acetonitrile T=20°C; 0.0833333 h; 2: sodium cyanide in acetonitrile T=20°C; 1 h;
参考文献
Sofighaderi, Sargol; Setamdideh, Davood
Oriental Journal of Chemistry, 2013 , vol. 29, # 3 p. 1135 - 1137
反应条件
ammonium chloride in methanol T=25°C; 12 h;
参考文献
Chaturvedula, Prasad V.; Pin, Sokhom; Tholady, George; Conway, Charlie M.; MacOr, John E.; Dubowchik, Gene M.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4719 - 4722
反应条件
1: sodium cyanide With (S)-hydroxynitrile lyase; acetic acid in water; isopropyl alcohol 48 h; Cooling with iceEnzymatic reaction; 2: 4-methoxy-benzaldehyde in water; isopropyl alcohol 48 h; Cooling with ice; enantioselective reaction;
参考文献
Zheng, Zubiao; Zi, Yan; Li, Zhongzhou; Zou, Xinzhuo
Tetrahedron Asymmetry, 2013 , vol. 24, # 8 p. 434 - 439
反应条件
in ethanol; water 2 h; Reflux;
参考文献
WO2011/71565 A1, ;
Page/Page column 146 ;
WO 2011/071565 A1
