773837-37-9合成路线 （共 596 条）
参考文献
Gmelin Handbook: C: MVol.D1, 3.4, page 31 - 44
反应条件
in neat (no solvent) byproducts: HCl, CO2; according to: W. C. Fernelius, ed., Inorganic syntheses, Vol. 2 (McGraw-Hill, New York, 1946); IR spectroscopy;
参考文献
Rajasekar; Kadossov, Evgueni B.; Ward, Lucas; Baker, Jennifer Lee; Materer, Nicholas F.
Journal of Physical Chemistry B, 2003 , vol. 107, # 31 p. 7726 - 7732
反应条件
hydrogenchloride in water byproducts: NaCl, H2O;
参考文献
Mauguin, C.; Simon, L.-J.
Ann. Chim. (Paris) (9), 1921 , vol. 15, p. 18 - 41
反应条件
in N,N-dimethyl-formamide T=80°C; 6 h;
参考文献
Szymanska, Ewa; Frydenvang, Karla; Contreras-Sanz, Alberto; Pickering, Darryl S.; Frola, Elena; Serafimoska, Zorica; Nielsen, Birgitte; Kastrup, Jette S.; Johansen, Tommy N.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 20 p. 7289 - 7298
反应条件
in nitric acid precipitation with 1 M NaCN solution at 25°C in presence of Tl(1+), Pb(2+), Ni(2+), Mn(2+), Zn(2+), UO2(2+), Rh(3+), La(3+), Ce(3+), Ce(4+), Th(4+), Cd(2+) or Fe(3+); grade of coprecipitation discussed;;
参考文献
Jackwerth, E.; Graffmann, G.
Zeitschrift fuer Analytische Chemie, 1970 , vol. 251, p. 81 - 91
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Gmelin Handbook: Ag: MVol.B3, 16.4.1.1, page 297 - 298
反应条件
in water; N,N-dimethyl-formamide T=65°C; 9 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2119706 A1, 2009 ;
Location in patent: Page/Page column 48 ;
EP 2119706 A1
反应条件
hydrogenchloride in water T=20°C; Large scale;
参考文献
Shaw, Nicholas M.; Brieden, Walter; De Riedmatten, Patricia; Roduit, Jean-Paul; Zimmermann, Bertin; Neumueller, Roman; Naughton, Andrew; Robins, Karen; Tinschert, Andreas; Schmid, Evelyne; Hischier, Marie-Louise; Venetz, Veronika; Werlen, Josef; Zimmermann, Thomas
Organic Process Research and Development, 2002 , vol. 6, # 4 p. 497 - 504
反应条件
in DMF (N,N-dimethyl-formamide) T=170°C; 18 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1424336 A1, 2004 ;
Location in patent: Page 41 ;
反应条件
1: 2-chloropyridine-N-oxide hydrochloride With methanol; potassium methanolate 0.166667 h; Cooling with ice; 2: With dimethyl sulfate T=20°C; 3 h; 3: sodium cyanide in water T=0°C;
参考文献
Tsukamoto, Issei; Koshio, Hiroyuki; Kuramochi, Takahiro; Saitoh, Chikashi; Yanai-Inamura, Hiroko; Kitada-Nozawa, Chika; Yamamoto, Eisaku; Yatsu, Takeyuki; Shimada, Yoshiaki; Sakamoto, Shuichi; Tsukamoto, Shin-ichi
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 8 p. 3130 - 3141
反应条件
iodine; chlorine in water 5percent NaCN soln.; extd. with ether and evapn.;
参考文献
Grignard, V.; Crouzier, P.
Bull. Soc. Chim. France (4), 1921 , vol. 29, p. 214 - 217
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Gmelin Handbook: C: MVol.D3, 6.2.6.1.1, page 241 - 242
