773837-37-9合成路线 （共 596 条）
反应条件
bromine in methanol T=0 - 20°C; Inert atmosphere;
参考文献
Lang, Kai; Park, Jongwoo; Hong, Sukwon
Journal of Organic Chemistry, 2010 , vol. 75, # 19 p. 6424 - 6435
反应条件
1: sodium cyanide; copper (I) cyanide in N,N-dimethyl-formamide T=125°C; 2: 3,5-dibromopyrazine-2-ylamine in N,N-dimethyl-formamide T=125°C; 5 h;
参考文献
Folmer, Brigitte Johanna Bernita; Man, de Adrianus Petrus Antonius; Gernette, Elisabeth Sophia; Corte Real Goncalves Azevedo, Rita; Ibrahim, Hemen
Patent: US2013/79341 A1, 2013 ;
Location in patent: Paragraph 0119 ;
反应条件
sodium tetrahydroborate in methanol; formamide
参考文献
Kwon, Tae Hoon; Yoon, Ik Hwan; Shin, Ji-Sun; Lee, Young Hun; Kwon, Bong Jin; Lee, Kyung-Tae; Lee, Yong Sup
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2571 - 2574
反应条件
in dimethyl sulfoxide T=90°C; 3 h;
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
Location in patent: Paragraph 0465 ;
反应条件
in ethanol; water T=80°C; 24 h;
参考文献
KOWA CO., LTD.; Morimoto, Toshiharu; Koshizawa, Tomoaki; Watanabe, Gen; Ohgiya, Tadaaki; Yamasaki, Nao; Inoue, Noriyuki
Patent: US2013/102621 A1, 2013 ;
Location in patent: Paragraph 0281; 0282 ;
反应条件
tetra-(n-butyl)ammonium iodide in dimethyl sulfoxide T=50°C; 15 h;
参考文献
Wang, Lihong; Prabhudas, Bodhuri; Clive, Derrick L. J.
Journal of the American Chemical Society, 2009 , vol. 131, p. 6003 - 6012
反应条件
1: sodium cyanide; methyl 3-Iodo-4-hydroxybenzoate With copper (I) cyanide in N,N-dimethyl-formamide T=120°C; 24 h; Inert atmosphere; 2: 2-iodo-propane With potassium carbonate in N,N-dimethyl-formamide T=90°C; 12 h; Cooling with ice;
参考文献
GLAXO WELLCOME HOUSE
Patent: US2012/283297 A1, 2012 ;
Location in patent: Page/Page column 17 ;
参考文献
Fabbrizzi, Luigi; Micheloni, Mauro; Paoletti, Piero
Inorganic Chemistry, 1980 , vol. 19, p. 535 - 538
反应条件
in dimethyl sulfoxide T=80°C; 2 h; Inert atmosphere;
参考文献
Mukherjee, Anupam; Liu, Rai-Shung
Organic Letters, 2011 , vol. 13, # 4 p. 660 - 663
反应条件
in dimethyl sulfoxide T=80°C; 4 h;
参考文献
Hack, Verena; Reuter, Cedric; Opitz, Robert; Schmieder, Peter; Beyermann, Michael; Neudoerfl, Joerg-Martin; Kuehne, Ronald; Schmalz, Hans-Guenther
Angewandte Chemie - International Edition, 2013 , vol. 52, # 36 p. 9539 - 9543
Angew. Chem., 2013 , vol. 125, # 36 p. 9718 - 9722
