773837-37-9合成路线 （共 596 条）
反应条件
in ethanol; N,N-dimethyl-formamide 15 h; Inert atmosphereReflux;
参考文献
Nguyen-Trung, Anh Thu; Tritsch, Denis; Grosdemange-Billiard, Catherine; Rohmer, Michel
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1643 - 1647
反应条件
in N,N-dimethyl-formamide T=60°C; 5 h;
参考文献
WO2010/86366 A1, ;
Page/Page column 40 ;
WO 2010/086366 A1
反应条件
in N,N-dimethyl-formamide T=100°C; 0.5 h;
参考文献
Tetrahedron Letters, , vol. 52, # 51 p. 6968 - 6970
反应条件
1: 3-PhCH2O-Ph-CH2OH With thionyl chloride in 1,2-dichloro-ethane T=0 - 20°C; 3 h; 2: sodium cyanide in DMF (N,N-dimethyl-formamide) T=50°C;
参考文献
TAKEDA CHEMICAL INDUSTRIES, LTD.
Patent: WO2003/99793 A1, 2003 ;
Location in patent: Page 158 ;
反应条件
in dimethyl sulfoxide T=150°C; 48 h; Product distribution / selectivity;
参考文献
F. HOFFMANN-LA ROCHE AG; BISSANTZ, Caterina; GRETHER, Uwe; HEBEISEN, Paul; KIMBARA, Atsushi; LIU, Qingping; NETTEKOVEN, Matthias; PRUNOTTO, Marco; ROEVER, Stephan; ROGERS-EVANS, Mark; SCHULZ-GASCH, Tanja; ULLMER, Christoph; WANG, Zhiwei; YANG, Wulun
Patent: WO2012/168350 A1, 2012 ;
Location in patent: Page/Page column 100 ;
WO 2012/168350 A1
反应条件
in dimethyl sulfoxide T=150°C; 77 h;
参考文献
G.D. Searle and Co.
Patent: EP1193265 A2, 2002 ;
Location in patent: Page 67 ;
参考文献
SHOWA DENKO K.K.; Kao Corporation
Patent: EP1435351 A1, 2004 ;
Location in patent: Page 6 ;
反应条件
copper(l) iodide; 1,10-phenanthroline in 1,4-dioxane T=145°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Do, Hien-Quang; Daugulis, Olafs
Organic Letters, 2010 , vol. 12, # 11 p. 2517 - 2519
反应条件
1: 1-bromo-3-butynol With sodium iodide in dimethyl sulfoxide T=0 - 20°C; 2 h; 2: sodium cyanide in dimethyl sulfoxide T=0 - 80°C;
参考文献
CALITHERA BIOSCIENCES INC.; LI, Jim; CHEN, Lijing; GOYAL, Bindu; LAIDIG, Guy; STANTON, Timothy, Friend; SJOGREN, Eric, Brian
Patent: WO2013/78123 A1, 2013 ;
Location in patent: Page/Page column 81; 82 ;
WO 2013/078123 A1
反应条件
in dimethyl sulfoxide T=80°C; 2 h; Inert atmosphere;
参考文献
Mukherjee, Anupam; Liu, Rai-Shung
Organic Letters, 2011 , vol. 13, # 4 p. 660 - 663
