2,2-二氟苯并[d][1,3]二氧代-5-羧酸甲酯合成路线 (共 5 条)
反应条件
1: With sodium hydroxide in methanol T=20°C; 2: With hydrogenchloride in water pH=3;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 26 ;
US 20120277224 A1
反应条件
triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride
T=100°C; 24 h;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 26 ;
US 20120277224 A1
反应条件
triethylamine; tetrakis (triphenylphosphine) palladium (0) in methanol; acetonitrile
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
sodium tetrahydroborate in tetrahydrofuran
T=0°C; 1 h; Product distribution / selectivity;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/21982 A2, 2007 ;
Location in patent: Page/Page column 64 ;
反应条件
1: sodium hydroxide; lithium aluminum hydride / tetrahydrofuran; water
2: thionyl chloride; sodium hydrogencarbonate / dichloromethane
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;