7-氟-3,4-二氢-2H-苯并[b]氧杂环庚三烯-5-酮合成路线 (共 4 条)
反应条件
sodium hydride in tetrahydrofuran
T=20°C; Inert atmosphere;
参考文献
Blaquiere, Nicole; Do, Steven; Dudley, Danette; Folkes, Adrian; Goldsmith, Richard; Heald, Robert; Heffron, Timothy; Kolesnikov, Aleksandr; Ndubaku, Chudi; Olivero, Alan G.; Price, Stephen; Staben, Steven; Wei, BinQing
Patent: US2011/76291 A1, 2011 ;
Location in patent: Page/Page column 237 ;
参考文献
Rueeger, Heinrich; Gerspacher, Marc; Buehlmayer, Peter; Rigollier, Pascal; Yamaguchi, Yasuchika; Schmidlin, Tibur; Whitebread, Steven; Nuesslein-Hildesheim, Barbara; Nick, Hanspeter; Cricione, Leoluca
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2451 - 2457
反应条件
1: NaOMe / ethanol; 1,2-dichloro-benzene / 150 °C
2: polyphosphoric acid / 110 °C
View Scheme
参考文献
Rueeger, Heinrich; Gerspacher, Marc; Buehlmayer, Peter; Rigollier, Pascal; Yamaguchi, Yasuchika; Schmidlin, Tibur; Whitebread, Steven; Nuesslein-Hildesheim, Barbara; Nick, Hanspeter; Cricione, Leoluca
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2451 - 2457
反应条件
1: potassium carbonate / butanone / Reflux; Inert atmosphere
2: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere
View Scheme
参考文献
Blaquiere, Nicole; Do, Steven; Dudley, Danette; Folkes, Adrian; Goldsmith, Richard; Heald, Robert; Heffron, Timothy; Kolesnikov, Aleksandr; Ndubaku, Chudi; Olivero, Alan G.; Price, Stephen; Staben, Steven; Wei, BinQing
Patent: US2011/76291 A1, 2011 ;