3-溴-4-甲氧基苯乙酸合成路线 (共 22 条)
反应条件
1: aq. NaOH solution 2: ethanolic KOH-solution View Scheme
参考文献
Yakugaku Zasshi, , vol. 53, p. 557,563; dtsch. Ref. S. 92
Chem.Abstr., , p. 4223
反应条件
1: hydrogen chloride 2: aq. NaOH solution 3: ethanolic KOH-solution View Scheme
参考文献
Yakugaku Zasshi, , vol. 53, p. 557,563; dtsch. Ref. S. 92
Chem.Abstr., , p. 4223
参考文献
Itsuu Kenkyusho Nempo, , # 9 p. 1,4; engl. Ref. S. 59, 62
Chem.Abstr., , p. 1399
反应条件
(i) aq. NaOH, (ii) aq. H2O2; Multistep reaction;
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 2234 - 2238
反应条件
nitrogen; boron tribromide in dichloromethane
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2004/62661 A1, 2004 ;
Location in patent: Page/Page column 28 ;
WO 2004/062661 A1
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=0°C; 3 h;
参考文献
MERCK SHARP andamp;; DOHME CORP.; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; TEUMELSAN, Nardos, H.; YANG, Lihu; ZHU, Yuping; WALSH, Shawn, P.
Patent: WO2010/129379 A1, 2010 ;
Location in patent: Page/Page column 76 ;
WO 2010/129379 A1
反应条件
trifluoroacetic acid; sodium t-butanolate; Pd(dba)2 in tetrahydrofuran; methanol; dichloromethane; toluene
参考文献
Symyx Technologies
Patent: US2002/72632 A1, 2002 ;
反应条件
lithium aluminium tetrahydride Title compound not separated from byproducts;
参考文献
Fujio, Mizue; Funatsu, Kimito; Goto, Mutsuo; Seki, Yoji; Mishima, Masaaki; Tsuno, Yuho
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 3 p. 1091 - 1096
反应条件
lithium aluminium tetrahydride Title compound not separated from byproducts;
参考文献
Fujio, Mizue; Funatsu, Kimito; Goto, Mutsuo; Seki, Yoji; Mishima, Masaaki; Tsuno, Yuho
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 3 p. 1091 - 1096
反应条件
hydrogenchloride in water T=80°C; 72 h;
参考文献
AMIRA PHARMACEUTICALS, INC.; HUTCHINSON, John Howard; STOCK, Nicholas Simon; ROPPE, Jeffrey Roger; VOLKOTS, Deborah
Patent: WO2010/39977 A2, 2010 ;
Location in patent: Page/Page column 106-107 ;
WO 2010/039977 A2