2-氨基-4-异丙基苯甲酸合成路线 （共 4 条）
反应条件
Diazotization.Zersetzung der Diazoniumverbindung mit Wasser;
参考文献
Widman
Chemische Berichte, 1886 , vol. 19, p. 258
Chemische Berichte, 1890 , vol. 23, p. 3079
反应条件
hydrogen; palladium 10 on activated carbon in methanol
P=760.051 Torr; 2 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2008/133753 A2, 2008 ;
Location in patent: Page/Page column 130 ;
反应条件
1: 32 percent / nitric acid / 3 h / 0 °C
2: 28 percent / dimethylformamide / 24 h / Heating
3: 68 percent / AcOH, aq. H2SO4 / Heating
4: hydrogen, NH4OH / Raney Ni / H2O
View Scheme
参考文献
Hays, Sheryl J.; Caprathe, Bradley W.; Gilmore, John L.; Amin, Nilam; Emmerling, Mark R.; Michael, Walter; Nadimpalli, Ravi; Nath, Rathna; Raser, Kadee J.; Stafford, Daniel; Watson, Desiree; Wang, Kevin; Jaen, Juan C.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 7 p. 1060 - 1067
反应条件
1: 28 percent / dimethylformamide / 24 h / Heating
2: 68 percent / AcOH, aq. H2SO4 / Heating
3: hydrogen, NH4OH / Raney Ni / H2O
View Scheme
参考文献
Hays, Sheryl J.; Caprathe, Bradley W.; Gilmore, John L.; Amin, Nilam; Emmerling, Mark R.; Michael, Walter; Nadimpalli, Ravi; Nath, Rathna; Raser, Kadee J.; Stafford, Daniel; Watson, Desiree; Wang, Kevin; Jaen, Juan C.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 7 p. 1060 - 1067
