1: N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine With TMS-SnBu3; cesium fluoride in N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere; 2: carbon dioxide in N,N-dimethyl-formamide T=100°C; P=7500.75 Torr; 3 h; Autoclave; 3: With hydrogenchloride in diethyl ether; water; N,N-dimethyl-formamide pH=2; Inert atmosphere;

1: carbon dioxide; N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine With toluene-4-sulfonic acid; cesium fluoride; Me2PhSiBpin in N,N-dimethyl-formamide T=20°C; P=3750.38 Torr; 3 h; 2: diazomethane in diethyl ether

1: carbon dioxide; N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine With TMS-SnBu3; cesium fluoride in N,N-dimethyl-formamide T=100°C; P=7500.75 Torr; 3 h; 2: diazomethane in diethyl ether

1.1: potassium carbonate; Na(1+)*O4S(1-) / tetrahydrofuran / 7 h / |Reflux 2.1: tetrahydrofuran / 0.33 h / -78 °C 3.1: cesium fluoride / N,N-dimethyl-formamide / 1 h / 20 °C / 760.05 Torr 3.2: 0.17 h / 0 °C View Scheme

formic acid in tetrahydrofuran; water T=20°C; 48 h; Inert atmosphere;