顺式-4-羟基-D-脯氨酸盐酸盐合成路线 （共 12 条）
反应条件
1: 77 percent / HCl (gas) / 5 h / Heating
2: 87 percent / Et3N / dioxane; H2O / 15 h / 50 °C
3: 89 percent / pyridine / 1.) 0 deg C, 1 h, 2.) room temperature, 48 h
4: 1.) Et4NOAc*4H2O, 2.) 1 N NaOH / 1.) benzene, reflux, 1.5 h, 2.) MeOH, 0 deg C
5: 45 percent / LiBH4 / tetrahydrofuran
6: 69 percent / pyridine
7: 34 percent / 1.) Na/NH3 (liq.) / tetrahydrofuran
View Scheme
参考文献
Baker, Gregory L.; Fritschel, Scott J.; Stille, John R.; Stille, John K.
Journal of Organic Chemistry, 1981 , vol. 46, # 14 p. 2954 - 2960
反应条件
1: 77 percent / HCl (gas) / 5 h / Heating
2: 87 percent / Et3N / dioxane; H2O / 15 h / 50 °C
3: 89 percent / pyridine / 1.) 0 deg C, 1 h, 2.) room temperature, 48 h
4: 1.) Et4NOAc*4H2O, 2.) 1 N NaOH / 1.) benzene, reflux, 1.5 h, 2.) MeOH, 0 deg C
5: 45 percent / LiBH4 / tetrahydrofuran
View Scheme
参考文献
Watanabe, Akiko; Kiyota, Naotoshi; Yamasaki, Tetsuo; Tanda, Kazuhiro; Miyagoe, Tatsunori; Sakamoto, Masanori; Otsuka, Masami
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 5 p. 1132 - 1139
