(2R,4S)-4-羟基-2-(羟甲基)-1-吡咯烷羧酸叔丁酯合成路线 （共 22 条）
反应条件
1: sodium hydrogencarbonate / 1,4-dioxane; water / 0 - 20 °C
2: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Watanabe, Akiko; Kiyota, Naotoshi; Yamasaki, Tetsuo; Tanda, Kazuhiro; Miyagoe, Tatsunori; Sakamoto, Masanori; Otsuka, Masami
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 5 p. 1132 - 1139
反应条件
1: 69 percent / pyridine
2: 34 percent / 1.) Na/NH3 (liq.) / tetrahydrofuran
View Scheme
参考文献
Baker, Gregory L.; Fritschel, Scott J.; Stille, John R.; Stille, John K.
Journal of Organic Chemistry, 1981 , vol. 46, # 14 p. 2954 - 2960
