6-(4-苄基氨基-3-硝基苯基)-5-甲基-2,3,4,5-四氢哒嗪-3-酮合成路线 （共 9 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol 2 h;
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
反应条件
hydrazine hydrate; acetic acid in ethanol
16 h; Reflux;
参考文献
NOVARTIS AG; SCHICKANEDER, Christian; RIEDEL, Michael; BISKUP, Kathrin; HEYDEMUeLLER, Heike; REINHARDT, Ingeborg
Patent: WO2011/124638 A1, 2011 ;
Location in patent: Page/Page column 21 ;
反应条件
hydrazine hydrate; acetic acid
T=80 - 85°C; Product distribution / selectivity;
参考文献
NOVARTIS AG; SCHICKANEDER, Christian; RIEDEL, Michael; BISKUP, Kathrin; HEYDEMUeLLER, Heike; REINHARDT, Ingeborg
Patent: WO2011/124638 A1, 2011 ;
Location in patent: Page/Page column 19-20 ;
反应条件
in butan-1-ol
20 h; Heating;
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
反应条件
1: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C
2: 86 percent / butan-1-ol / 20 h / Heating
View Scheme
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
反应条件
1: 54.6 percent / conc. HCl, water / Heating
2: 98 percent / nitric acid / 0.5 h / -15 - -10 °C
3: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C
4: 86 percent / butan-1-ol / 20 h / Heating
View Scheme
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
反应条件
1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C
2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C
3: 86 percent / butan-1-ol / 20 h / Heating
View Scheme
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
反应条件
1: sodium cyanide / dimethylformamide / 2 h / 40 °C
2: 54.6 percent / conc. HCl, water / Heating
3: 98 percent / nitric acid / 0.5 h / -15 - -10 °C
4: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C
5: 86 percent / butan-1-ol / 20 h / Heating
View Scheme
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
反应条件
1: ethanol / 7.33 h / 40 - 50 °C / Reflux
2: hydrogenchloride / Reflux
3: hydrazine hydrate; acetic acid / ethanol / 16 h / Reflux
View Scheme
参考文献
NOVARTIS AG; SCHICKANEDER, Christian; RIEDEL, Michael; BISKUP, Kathrin; HEYDEMUeLLER, Heike; REINHARDT, Ingeborg
Patent: WO2011/124638 A1, 2011 ;
