4-苯基-2-吡咯烷酮-1-乙酰胺合成路线 （共 7 条）
反应条件
ammonia in methanol T=45 - 50°C; 5 h;
参考文献
Pharmaceutical Chemistry Journal, , vol. 14, # 11 p. 776 - 780
Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 11 p. 43 - 48
反应条件
ammonium hydroxide 2 h;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979
反应条件
1: 1) KOH / 1) DMSO, benzene, reflux, 8 h, 2) DMSO, benzene, RT, 1 d 2: 64 percent / 25percent aq. NH3 / 2 h View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979
反应条件
1: 94 percent / Me3SiOTf / 0.5 h / 150 - 155 °C 2: 81 percent / 25percent aq. NH3 / 2 h View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979
反应条件
1: 99 percent / 3 h / Heating 2: 94 percent / Me3SiOTf / 0.5 h / 150 - 155 °C 3: 81 percent / 25percent aq. NH3 / 2 h View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979
反应条件
1: 58 percent / 0.5 h / 190 °C 2: 1.) NaH / 1.) dioxane, 90 deg C, 1 h, 2.) 125 deg C, 5 h 3: 100 percent / NH3 / methanol / 5 h / 45 - 50 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 14, # 11 p. 776 - 780
Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 11 p. 43 - 48
反应条件
1: 89.6 percent / 10percent aq. KOH / 5 h / Heating 2: 58 percent / 0.5 h / 190 °C 3: 1.) NaH / 1.) dioxane, 90 deg C, 1 h, 2.) 125 deg C, 5 h 4: 100 percent / NH3 / methanol / 5 h / 45 - 50 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 14, # 11 p. 776 - 780
Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 11 p. 43 - 48
