2-[(5-氟-2,4-二氧代-3,4-二氢-1(2H)-嘧啶基)甲氧基]乙基乙酸酯合成路线 （共 6 条）
反应条件
chloro-trimethyl-silane; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane
1.) reflux, 3 h, 2.) a) RT, 18 h, b) reflux, 5 d; Yield given. Multistep reaction;
参考文献
Kelley, James L.; Kelsey, John E.; Hall, William R.; Krochmal, Mark P.; Schaeffer, Howard J.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 753 - 756
反应条件
ammonium sulfate; CsI
2.) acetonitrile, reflux, 4 h; Yield given. Multistep reaction;
参考文献
Kim, Yong Hae; Kim, Joong Young; Lee, Chun Ho
Chemistry Letters, 1988 , p. 1045 - 1048
反应条件
tin(IV) chloride
1.) CH2Cl2, RT, 3 h, 2.) CH2Cl2, RT, overnight; Yield given. Multistep reaction;
参考文献
Rosowsky; Kim; Wick
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1177 - 1181
参考文献
Ochi; Miyamoto; Miura; Mitsui; Matsunaga; Shindo
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1703 - 1706
参考文献
Karpeiskii, M. Ya.; Mikhailov, S. M.; Tsieminya, A. S.; Ziderman, A. A.; Kravchenko, I. M.; et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980 , vol. 16, # 11 p. 1176 - 1179
Khimiya Geterotsiklicheskikh Soedinenii, 1980 , vol. 16, # 11 p. 1541 - 1544
反应条件
1.) acetonitrile, 0 degC, 2.) 0 degC to R.T. 2 h; Yield given. Multistep reaction;
参考文献
Robins; Hatfield
Canadian Journal of Chemistry, 1982 , vol. 60, # 5 p. 547 - 553
